The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Published

Journal Article

Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment, which included an increase in T cell homing factors, erythropoiesis, and adipogenesis. Adipocytes, as well as CXCR4-CXCL12 and S1P-S1P1R interactions, contributed to enhanced T cell accumulation in BM during DR. Memory T cell homing to BM during DR was associated with enhanced protection against infections and tumors. Together, this work uncovers a fundamental host strategy to sustain and optimize immunological memory during nutritional challenges that involved a temporal and spatial reorganization of the memory pool within "safe haven" compartments.

Full Text

Duke Authors

Cited Authors

  • Collins, N; Han, S-J; Enamorado, M; Link, VM; Huang, B; Moseman, EA; Kishton, RJ; Shannon, JP; Dixit, D; Schwab, SR; Hickman, HD; Restifo, NP; McGavern, DB; Schwartzberg, PL; Belkaid, Y

Published Date

  • August 22, 2019

Published In

Volume / Issue

  • 178 / 5

Start / End Page

  • 1088 - 1101.e15

PubMed ID

  • 31442402

Pubmed Central ID

  • 31442402

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2019.07.049

Language

  • eng

Conference Location

  • United States