Positive affect and medication adherence in chronic conditions: A systematic review.

Journal Article (Systematic Review;Journal Article)


This review aims to inform research and clinical care on the current state of knowledge on the relationship between positive affect and medication adherence.


Searches were carried out in PsycINFO, PubMed MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, and Embase. There were no limits on study type, publication date, language, or participant demographics. Studies reporting a relationship between positive affect and medication adherence were eligible for inclusion if positive affect was measured prior to or concurrently with medication adherence.


Nine studies met inclusion criteria. All studies were prospective cohort or cross-sectional and examined positive affect and medication adherence in people living with HIV or cardiovascular conditions. The majority of results indicated positive associations between positive affect and medication adherence, with Cohen's d effect sizes ranging from -0.40 to 1.27.


Consistent with previous theoretical work, this systematic review provides evidence of a link between positive affect and improved medication adherence. Better measurement of both affect and medication adherence across chronic conditions is an important focus for future research and will inform targeted interventions to improve adherence and, ultimately, decrease the morbidity, mortality, and cost associated with suboptimal adherence in chronic physical conditions. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Full Text

Duke Authors

Cited Authors

  • Bassett, SM; Schuette, SA; O'Dwyer, LC; Moskowitz, JT

Published Date

  • November 2019

Published In

Volume / Issue

  • 38 / 11

Start / End Page

  • 960 - 974

PubMed ID

  • 31368717

Pubmed Central ID

  • PMC6800780

Electronic International Standard Serial Number (EISSN)

  • 1930-7810

International Standard Serial Number (ISSN)

  • 0278-6133

Digital Object Identifier (DOI)

  • 10.1037/hea0000778


  • eng