Skip to main content
Journal cover image

Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.

Publication ,  Journal Article
Wang, S; Tzankov, A; Xu-Monette, ZY; Hoeller, S; Wang, SA; Richards, KL; Zhang, S; Said, JW; Medeiros, LJ; Young, KH
Published in: Human pathology
December 2013

Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.

Duke Scholars

Published In

Human pathology

DOI

EISSN

1532-8392

ISSN

0046-8177

Publication Date

December 2013

Volume

44

Issue

12

Start / End Page

2658 / 2667

Related Subject Headings

  • Pathology
  • Male
  • Lymphoma, Mantle-Cell
  • Lymphoma, Follicular
  • Lymph Nodes
  • Immunoglobulin Heavy Chains
  • Humans
  • Female
  • Cyclin D1
  • Composite Lymphoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, S., Tzankov, A., Xu-Monette, Z. Y., Hoeller, S., Wang, S. A., Richards, K. L., … Young, K. H. (2013). Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Human Pathology, 44(12), 2658–2667. https://doi.org/10.1016/j.humpath.2013.07.007
Wang, Shi, Alexander Tzankov, Zijun Y. Xu-Monette, Sylvia Hoeller, Sa A. Wang, Kristy L. Richards, Shanxiang Zhang, Jonathan W. Said, L Jeffrey Medeiros, and Ken H. Young. “Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.Human Pathology 44, no. 12 (December 2013): 2658–67. https://doi.org/10.1016/j.humpath.2013.07.007.
Wang S, Tzankov A, Xu-Monette ZY, Hoeller S, Wang SA, Richards KL, et al. Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Human pathology. 2013 Dec;44(12):2658–67.
Wang, Shi, et al. “Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.Human Pathology, vol. 44, no. 12, Dec. 2013, pp. 2658–67. Epmc, doi:10.1016/j.humpath.2013.07.007.
Wang S, Tzankov A, Xu-Monette ZY, Hoeller S, Wang SA, Richards KL, Zhang S, Said JW, Medeiros LJ, Young KH. Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Human pathology. 2013 Dec;44(12):2658–2667.
Journal cover image

Published In

Human pathology

DOI

EISSN

1532-8392

ISSN

0046-8177

Publication Date

December 2013

Volume

44

Issue

12

Start / End Page

2658 / 2667

Related Subject Headings

  • Pathology
  • Male
  • Lymphoma, Mantle-Cell
  • Lymphoma, Follicular
  • Lymph Nodes
  • Immunoglobulin Heavy Chains
  • Humans
  • Female
  • Cyclin D1
  • Composite Lymphoma