Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.
Journal Article (Journal Article)
Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.
Full Text
Duke Authors
Cited Authors
- Wang, S; Tzankov, A; Xu-Monette, ZY; Hoeller, S; Wang, SA; Richards, KL; Zhang, S; Said, JW; Medeiros, LJ; Young, KH
Published Date
- December 2013
Published In
Volume / Issue
- 44 / 12
Start / End Page
- 2658 - 2667
PubMed ID
- 24071012
Electronic International Standard Serial Number (EISSN)
- 1532-8392
Digital Object Identifier (DOI)
- 10.1016/j.humpath.2013.07.007
Language
- eng
Conference Location
- United States