Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Journal Article
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Full Text
Duke Authors
Cited Authors
- Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrera, CP; Karaman, I; Ng, FL; Evangelou, M; Witkowska, K; Tzanis, E; Hellwege, JN; Giri, A; Velez Edwards, DR; Sun, YV; Cho, K; Gaziano, JM; Wilson, PWF; Tsao, PS; Kovesdy, CP; Esko, T; Mägi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Giulianini, F; Holliday, EG; Jackson, AU; Li-Gao, R; Lin, W-Y; Luan, J; Mangino, M; Oldmeadow, C; Prins, BP; Qian, Y; Sargurupremraj, M; Shah, N; Surendran, P; Thériault, S; Verweij, N; Willems, SM; Zhao, J-H; Amouyel, P; Connell, J; de Mutsert, R; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Paré, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Chauhan, G; Ciullo, M; Cocca, M; Collins, F; Cordell, HJ; Davies, G; de Borst, MH; de Geus, EJ; Deary, IJ; Deelen, J; Del Greco M, F; Demirkale, CY; Dörr, M; Ehret, GB; Elosua, R; Enroth, S; Erzurumluoglu, AM; Ferreira, T; Frånberg, M; Franco, OH; Gandin, I; Gasparini, P; Giedraitis, V; Gieger, C; Girotto, G; Goel, A; Gow, AJ; Gudnason, V; Guo, X; Gyllensten, U; Hamsten, A; Harris, TB; Harris, SE; Hartman, CA; Havulinna, AS; Hicks, AA; Hofer, E; Hofman, A; Hottenga, J-J; Huffman, JE; Hwang, S-J; Ingelsson, E; James, A; Jansen, R; Jarvelin, M-R; Joehanes, R; Johansson, Å; Johnson, AD; Joshi, PK; Jousilahti, P; Jukema, JW; Jula, A; Kähönen, M; Kathiresan, S; Keavney, BD; Khaw, K-T; Knekt, P; Knight, J; Kolcic, I; Kooner, JS; Koskinen, S; Kristiansson, K; Kutalik, Z; Laan, M; Larson, M; Launer, LJ; Lehne, B; Lehtimäki, T; Liewald, DCM; Lin, L; Lind, L; Lindgren, CM; Liu, Y; Loos, RJF; Lopez, LM; Lu, Y; Lyytikäinen, L-P; Mahajan, A; Mamasoula, C; Marrugat, J; Marten, J; Milaneschi, Y; Morgan, A; Morris, AP; Morrison, AC; Munson, PJ; Nalls, MA; Nandakumar, P; Nelson, CP; Niiranen, T; Nolte, IM; Nutile, T; Oldehinkel, AJ; Oostra, BA; O'Reilly, PF; Org, E; Padmanabhan, S; Palmas, W; Palotie, A; Pattie, A; Penninx, BWJH; Perola, M; Peters, A; Polasek, O; Pramstaller, PP; Nguyen, QT; Raitakari, OT; Ren, M; Rettig, R; Rice, K; Ridker, PM; Ried, JS; Riese, H; Ripatti, S; Robino, A; Rose, LM; Rotter, JI; Rudan, I; Ruggiero, D; Saba, Y; Sala, CF; Salomaa, V; Samani, NJ; Sarin, A-P; Schmidt, R; Schmidt, H; Shrine, N; Siscovick, D; Smith, AV; Snieder, H; Sõber, S; Sorice, R; Starr, JM; Stott, DJ; Strachan, DP; Strawbridge, RJ; Sundström, J; Swertz, MA; Taylor, KD; Teumer, A; Tobin, MD; Tomaszewski, M; Toniolo, D; Traglia, M; Trompet, S; Tuomilehto, J; Tzourio, C; Uitterlinden, AG; Vaez, A; van der Most, PJ; van Duijn, CM; Vergnaud, A-C; Verwoert, GC; Vitart, V; Völker, U; Vollenweider, P; Vuckovic, D; Watkins, H; Wild, SH; Willemsen, G; Wilson, JF; Wright, AF; Yao, J; Zemunik, T; Zhang, W; Attia, JR; Butterworth, AS; Chasman, DI; Conen, D; Cucca, F; Danesh, J; Hayward, C; Howson, JMM; Laakso, M; Lakatta, EG; Langenberg, C; Melander, O; Mook-Kanamori, DO; Palmer, CNA; Risch, L; Scott, RA; Scott, RJ; Sever, P; Spector, TD; van der Harst, P; Wareham, NJ; Zeggini, E; Levy, D; Munroe, PB; Newton-Cheh, C; Brown, MJ; Metspalu, A; Hung, AM; O'Donnell, CJ; Edwards, TL; Psaty, BM; Tzoulaki, I; Barnes, MR; Wain, LV; Elliott, P; Caulfield, MJ; Million Veteran Program,
Published Date
- October 2018
Published In
Volume / Issue
- 50 / 10
Start / End Page
- 1412 - 1425
PubMed ID
- 30224653
Pubmed Central ID
- 30224653
Electronic International Standard Serial Number (EISSN)
- 1546-1718
Digital Object Identifier (DOI)
- 10.1038/s41588-018-0205-x
Language
- eng
Conference Location
- United States