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Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.

Publication ,  Journal Article
Mozaffarian, D; Dashti, HS; Wojczynski, MK; Chu, AY; Nettleton, JA; Männistö, S; Kristiansson, K; Reedik, M; Lahti, J; Houston, DK; Kanoni, S ...
Published in: PLoS One
2017

BACKGROUND: Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines. Yet, their intakes remain remarkably variable both within and across populations, which could partly owe to genetic influences. OBJECTIVE: To identify common genetic variants that influence fish and dietary eicosapentaenoic acid plus docosahexaenoic acid (EPA+DHA) consumption. DESIGN: We conducted genome-wide association (GWA) meta-analysis of fish (n = 86,467) and EPA+DHA (n = 62,265) consumption in 17 cohorts of European descent from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium Nutrition Working Group. Results from cohort-specific GWA analyses (additive model) for fish and EPA+DHA consumption were adjusted for age, sex, energy intake, and population stratification, and meta-analyzed separately using fixed-effect meta-analysis with inverse variance weights (METAL software). Additionally, heritability was estimated in 2 cohorts. RESULTS: Heritability estimates for fish and EPA+DHA consumption ranged from 0.13-0.24 and 0.12-0.22, respectively. A significant GWA for fish intake was observed for rs9502823 on chromosome 6: each copy of the minor allele (FreqA = 0.015) was associated with 0.029 servings/day (~1 serving/month) lower fish consumption (P = 1.96x10-8). No significant association was observed for EPA+DHA, although rs7206790 in the obesity-associated FTO gene was among top hits (P = 8.18x10-7). Post-hoc calculations demonstrated 95% statistical power to detect a genetic variant associated with effect size of 0.05% for fish and 0.08% for EPA+DHA. CONCLUSIONS: These novel findings suggest that non-genetic personal and environmental factors are principal determinants of the remarkable variation in fish consumption, representing modifiable targets for increasing intakes among all individuals. Genes underlying the signal at rs72838923 and mechanisms for the association warrant further investigation.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

12

Start / End Page

e0186456

Location

United States

Related Subject Headings

  • White People
  • United States
  • Seafood
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study
  • General Science & Technology
  • Female
  • Europe
 

Citation

APA
Chicago
ICMJE
MLA
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Mozaffarian, D., Dashti, H. S., Wojczynski, M. K., Chu, A. Y., Nettleton, J. A., Männistö, S., … Tanaka, T. (2017). Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One, 12(12), e0186456. https://doi.org/10.1371/journal.pone.0186456
Mozaffarian, Dariush, Hassan S. Dashti, Mary K. Wojczynski, Audrey Y. Chu, Jennifer A. Nettleton, Satu Männistö, Kati Kristiansson, et al. “Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.PLoS One 12, no. 12 (2017): e0186456. https://doi.org/10.1371/journal.pone.0186456.
Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, et al. Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One. 2017;12(12):e0186456.
Mozaffarian, Dariush, et al. “Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.PLoS One, vol. 12, no. 12, 2017, p. e0186456. Pubmed, doi:10.1371/journal.pone.0186456.
Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K, Reedik M, Lahti J, Houston DK, Cornelis MC, van Rooij FJA, Dimitriou M, Kanoni S, Mikkilä V, Steffen LM, de Oliveira Otto MC, Qi L, Psaty B, Djousse L, Rotter JI, Harald K, Perola M, Rissanen H, Jula A, Krista F, Mihailov E, Feitosa MF, Ngwa JS, Xue L, Jacques PF, Perälä M-M, Palotie A, Liu Y, Nalls NA, Ferrucci L, Hernandez D, Manichaikul A, Tsai MY, Kiefte-de Jong JC, Hofman A, Uitterlinden AG, Rallidis L, Ridker PM, Rose LM, Buring JE, Lehtimäki T, Kähönen M, Viikari J, Lemaitre R, Salomaa V, Knekt P, Metspalu A, Borecki IB, Cupples LA, Eriksson JG, Kritchevsky SB, Bandinelli S, Siscovick D, Franco OH, Deloukas P, Dedoussis G, Chasman DI, Raitakari O, Tanaka T. Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One. 2017;12(12):e0186456.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2017

Volume

12

Issue

12

Start / End Page

e0186456

Location

United States

Related Subject Headings

  • White People
  • United States
  • Seafood
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study
  • General Science & Technology
  • Female
  • Europe