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Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.

Publication ,  Journal Article
Singh, J; Minster, RL; Schupf, N; Kraja, A; Liu, Y; Christensen, K; Newman, AB; Kammerer, CM
Published in: J Gerontol A Biol Sci Med Sci
October 1, 2017

BACKGROUND: Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity. METHODS: Using data from the Long Life Family Study, we performed genomewide association analyses on an endophenotype construct, LF1, comprising a linear combination of traits across health domains. LF1 primarily reflected traits from the pulmonary and physical activity domains. RESULTS: We detected a significant association between LF1 and a locus on chromosome 10p15 (p-value = 4.65 × 10-8) and suggestive evidence (p-value < 5 × 10-6) for association on chromosomes 1, 2, 8, 12, 15, 18, and 22. Using data from the Health, Aging and Body Composition Study, we subsequently replicated the association for the 1p13 region near the NBPF6 locus (p-value = 3.65 × 10-4). CONCLUSIONS: Our analyses indicate that loci influencing a healthy aging endophenotype construct predominantly comprised of pulmonary and physical function domains may be located on chromosome 1p13 near the NBPF6 locus. Further investigation of this possible locus and other suggestive loci may reveal novel biological pathways that influence healthy aging.

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

October 1, 2017

Volume

72

Issue

10

Start / End Page

1411 / 1416

Location

United States

Related Subject Headings

  • United States
  • Respiratory Function Tests
  • Polymorphism, Single Nucleotide
  • Physical Fitness
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Haplotypes
  • Gerontology
 

Citation

APA
Chicago
ICMJE
MLA
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Singh, J., Minster, R. L., Schupf, N., Kraja, A., Liu, Y., Christensen, K., … Kammerer, C. M. (2017). Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. J Gerontol A Biol Sci Med Sci, 72(10), 1411–1416. https://doi.org/10.1093/gerona/glx011
Singh, Jatinder, Ryan L. Minster, Nicole Schupf, Aldi Kraja, YongMei Liu, Kaare Christensen, Anne B. Newman, and Candace M. Kammerer. “Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.J Gerontol A Biol Sci Med Sci 72, no. 10 (October 1, 2017): 1411–16. https://doi.org/10.1093/gerona/glx011.
Singh J, Minster RL, Schupf N, Kraja A, Liu Y, Christensen K, et al. Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1411–6.
Singh, Jatinder, et al. “Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study.J Gerontol A Biol Sci Med Sci, vol. 72, no. 10, Oct. 2017, pp. 1411–16. Pubmed, doi:10.1093/gerona/glx011.
Singh J, Minster RL, Schupf N, Kraja A, Liu Y, Christensen K, Newman AB, Kammerer CM. Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1411–1416.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

October 1, 2017

Volume

72

Issue

10

Start / End Page

1411 / 1416

Location

United States

Related Subject Headings

  • United States
  • Respiratory Function Tests
  • Polymorphism, Single Nucleotide
  • Physical Fitness
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Haplotypes
  • Gerontology