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1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

Publication ,  Journal Article
Gorski, M; van der Most, PJ; Teumer, A; Chu, AY; Li, M; Mijatovic, V; Nolte, IM; Cocca, M; Taliun, D; Gomez, F; Li, Y; Tayo, B; Tin, A ...
Published in: Sci Rep
April 28, 2017

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

April 28, 2017

Volume

7

Start / End Page

45040

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Kidney
  • Humans
  • Genotyping Techniques
  • Genome-Wide Association Study
  • Genome, Human
  • Genetic Loci
  • Gene Frequency
  • Computational Biology
 

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APA
Chicago
ICMJE
MLA
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Gorski, M., van der Most, P. J., Teumer, A., Chu, A. Y., Li, M., Mijatovic, V., … Fuchsberger, C. (2017). 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep, 7, 45040. https://doi.org/10.1038/srep45040
Gorski, Mathias, Peter J. van der Most, Alexander Teumer, Audrey Y. Chu, Man Li, Vladan Mijatovic, Ilja M. Nolte, et al. “1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.Sci Rep 7 (April 28, 2017): 45040. https://doi.org/10.1038/srep45040.
Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, et al. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017 Apr 28;7:45040.
Gorski, Mathias, et al. “1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.Sci Rep, vol. 7, Apr. 2017, p. 45040. Pubmed, doi:10.1038/srep45040.
Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger EP, Chen M-H, Chouraki V, Ciullo M, Coresh J, Cornelis MC, Curhan GC, d’Adamo AP, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco OH, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock SJ, Harris TB, Helmer C, Höllerer S, Hofer E, Hofman A, Holliday EG, Homuth G, Hu FB, Huth C, Hutri-Kähönen N, Hwang S-J, Imboden M, Johansson Å, Kähönen M, König W, Kramer H, Krämer BK, Kumar A, Kutalik Z, Lambert J-C, Launer LJ, Lehtimäki T, de Borst M, Navis G, Swertz M, Liu Y, Lohman K, Loos RJF, Lu Y, Lyytikäinen L-P, McEvoy MA, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel AJ, Olden M, Wjh Penninx B, Pistis G, Pramstaller PP, Probst-Hensch N, Raitakari OT, Rettig R, Ridker PM, Rivadeneira F, Robino A, Rosas SE, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmidt R, Scott RJ, Sedaghat S, Smith AV, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden AG, Ulivi S, Viikari JS, Völker U, Vollenweider P, Völzke H, Vuckovic D, Waldenberger M, Jin Wang J, Yang Q, Chasman DI, Tromp G, Snieder H, Heid IM, Fox CS, Köttgen A, Pattaro C, Böger CA, Fuchsberger C. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017 Apr 28;7:45040.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

April 28, 2017

Volume

7

Start / End Page

45040

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Kidney
  • Humans
  • Genotyping Techniques
  • Genome-Wide Association Study
  • Genome, Human
  • Genetic Loci
  • Gene Frequency
  • Computational Biology