Skip to main content

Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.

Publication ,  Journal Article
Hodonsky, CJ; Jain, D; Schick, UM; Morrison, JV; Brown, L; McHugh, CP; Schurmann, C; Chen, DD; Liu, YM; Auer, PL; Laurie, CA; Taylor, KD ...
Published in: PLoS Genet
April 2017

Prior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies have not included individuals with an Amerindian ancestral background, such as Hispanics/Latinos, nor evaluated the full spectrum of genomic variation beyond single nucleotide variants. Using a custom genotyping array enriched for Amerindian ancestral content and 1000 Genomes imputation, we performed GWAS in 12,502 participants of Hispanic Community Health Study and Study of Latinos (HCHS/SOL) for hematocrit, hemoglobin, RBC count, RBC distribution width (RDW), and RBC indices. Approximately 60% of previously reported RBC trait loci generalized to HCHS/SOL Hispanics/Latinos, including African ancestral alpha- and beta-globin gene variants. In addition to the known 3.8kb alpha-globin copy number variant, we identified an Amerindian ancestral association in an alpha-globin regulatory region on chromosome 16p13.3 for mean corpuscular volume and mean corpuscular hemoglobin. We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140). Among the proxy variants at the SLC12A2 locus we identified rs3812049, located in a bi-directional promoter between SLC12A2 (which encodes a red cell membrane ion-transport protein) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant. We further demonstrate that disruption of the regulatory element harboring rs3812049 affects transcription of SLC12A2 and LINC01184 in human erythroid progenitor cells. Together, these results reinforce the importance of genetic study of diverse ancestral populations, in particular Hispanics/Latinos.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

April 2017

Volume

13

Issue

4

Start / End Page

e1006760

Location

United States

Related Subject Headings

  • beta-Globins
  • alpha-Globins
  • Tumor Suppressor Proteins
  • Solute Carrier Family 12, Member 2
  • RNA, Long Noncoding
  • Proteasome Endopeptidase Complex
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Homeodomain Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hodonsky, C. J., Jain, D., Schick, U. M., Morrison, J. V., Brown, L., McHugh, C. P., … Reiner, A. P. (2017). Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. PLoS Genet, 13(4), e1006760. https://doi.org/10.1371/journal.pgen.1006760
Hodonsky, Chani J., Deepti Jain, Ursula M. Schick, Jean V. Morrison, Lisa Brown, Caitlin P. McHugh, Claudia Schurmann, et al. “Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.PLoS Genet 13, no. 4 (April 2017): e1006760. https://doi.org/10.1371/journal.pgen.1006760.
Hodonsky CJ, Jain D, Schick UM, Morrison JV, Brown L, McHugh CP, et al. Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. PLoS Genet. 2017 Apr;13(4):e1006760.
Hodonsky, Chani J., et al. “Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.PLoS Genet, vol. 13, no. 4, Apr. 2017, p. e1006760. Pubmed, doi:10.1371/journal.pgen.1006760.
Hodonsky CJ, Jain D, Schick UM, Morrison JV, Brown L, McHugh CP, Schurmann C, Chen DD, Liu YM, Auer PL, Laurie CA, Taylor KD, Browning BL, Li Y, Papanicolaou G, Rotter JI, Kurita R, Nakamura Y, Browning SR, Loos RJF, North KE, Laurie CC, Thornton TA, Pankratz N, Bauer DE, Sofer T, Reiner AP. Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos. PLoS Genet. 2017 Apr;13(4):e1006760.

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

April 2017

Volume

13

Issue

4

Start / End Page

e1006760

Location

United States

Related Subject Headings

  • beta-Globins
  • alpha-Globins
  • Tumor Suppressor Proteins
  • Solute Carrier Family 12, Member 2
  • RNA, Long Noncoding
  • Proteasome Endopeptidase Complex
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Homeodomain Proteins