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Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.

Publication ,  Journal Article
Schick, UM; Jain, D; Hodonsky, CJ; Morrison, JV; Davis, JP; Brown, L; Sofer, T; Conomos, MP; Schurmann, C; McHugh, CP; Nelson, SC; Stilp, A ...
Published in: Am J Hum Genet
February 4, 2016
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Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five genes (ACTN1, ETV7, GABBR1-MOG, MEF2C, and ZBTB9-BAK1). Our strongest association was with Amerindian-specific variant rs117672662 (p value = 1.16 × 10(-28)) in ACTN1, a gene implicated in congenital macrothrombocytopenia. rs117672662 exhibited allelic differences in transcriptional activity and protein binding in hematopoietic cells. Our results underscore the value of diverse populations to extend insights into the allelic architecture of complex traits.

Duke Scholars

Yongmei Liu
Author Yongmei Liu Medicine, Cardiology
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Published In

Am J Hum Genet

DOI

10.1016/j.ajhg.2015.12.003

EISSN

1537-6605

Publication Date

February 4, 2016

Volume

98

Issue

2

Start / End Page

229 / 242

Location

United States

Related Subject Headings

  • Young Adult
  • Receptors, GABA-B
  • Polymorphism, Single Nucleotide
  • Platelet Count
  • Phenotype
  • Middle Aged
  • Membrane Proteins
  • MEF2 Transcription Factors
  • Humans
  • Hispanic or Latino
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schick, U. M., Jain, D., Hodonsky, C. J., Morrison, J. V., Davis, J. P., Brown, L., … Reiner, A. P. (2016). Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans. Am J Hum Genet, 98(2), 229–242. https://doi.org/10.1016/j.ajhg.2015.12.003
Schick, Ursula M., Deepti Jain, Chani J. Hodonsky, Jean V. Morrison, James P. Davis, Lisa Brown, Tamar Sofer, et al. “Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.” Am J Hum Genet 98, no. 2 (February 4, 2016): 229–42. https://doi.org/10.1016/j.ajhg.2015.12.003.
Schick UM, Jain D, Hodonsky CJ, Morrison JV, Davis JP, Brown L, et al. Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans. Am J Hum Genet. 2016 Feb 4;98(2):229–42.
Schick, Ursula M., et al. “Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.” Am J Hum Genet, vol. 98, no. 2, Feb. 2016, pp. 229–42. Pubmed, doi:10.1016/j.ajhg.2015.12.003.
Schick UM, Jain D, Hodonsky CJ, Morrison JV, Davis JP, Brown L, Sofer T, Conomos MP, Schurmann C, McHugh CP, Nelson SC, Vadlamudi S, Stilp A, Plantinga A, Baier L, Bien SA, Gogarten SM, Laurie CA, Taylor KD, Liu Y, Auer PL, Franceschini N, Szpiro A, Rice K, Kerr KF, Rotter JI, Hanson RL, Papanicolaou G, Rich SS, Loos RJF, Browning BL, Browning SR, Weir BS, Laurie CC, Mohlke KL, North KE, Thornton TA, Reiner AP. Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans. Am J Hum Genet. 2016 Feb 4;98(2):229–242.
Journal cover image

Published In

Am J Hum Genet

DOI

10.1016/j.ajhg.2015.12.003

EISSN

1537-6605

Publication Date

February 4, 2016

Volume

98

Issue

2

Start / End Page

229 / 242

Location

United States

Related Subject Headings

  • Young Adult
  • Receptors, GABA-B
  • Polymorphism, Single Nucleotide
  • Platelet Count
  • Phenotype
  • Middle Aged
  • Membrane Proteins
  • MEF2 Transcription Factors
  • Humans
  • Hispanic or Latino