Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children.

Journal Article (Journal Article)

The American Psychiatric Association estimates that 3 to 7 per cent of all school aged children are diagnosed with attention deficit hyperactivity disorder (ADHD). Even after correcting for general cognitive ability, numerous studies report a negative association between ADHD and educational achievement. With polygenic scores we examined whether genetic variants that have a positive influence on educational attainment have a protective effect against ADHD. The effect sizes from a large GWA meta-analysis of educational attainment in adults were used to calculate polygenic scores in an independent sample of 12-year-old children from the Netherlands Twin Register. Linear mixed models showed that the polygenic scores significantly predicted educational achievement, school performance, ADHD symptoms and attention problems in children. These results confirm the genetic overlap between ADHD and educational achievement, indicating that one way to gain insight into genetic variants responsible for variation in ADHD is to include data on educational achievement, which are available at a larger scale.

Full Text

Duke Authors

Cited Authors

  • de Zeeuw, EL; van Beijsterveldt, CEM; Glasner, TJ; Bartels, M; Ehli, EA; Davies, GE; Hudziak, JJ; Social Science Genetic Association Consortium, ; Rietveld, CA; Groen-Blokhuis, MM; Hottenga, JJ; de Geus, EJC; Boomsma, DI

Published Date

  • September 2014

Published In

Volume / Issue

  • 165B / 6

Start / End Page

  • 510 - 520

PubMed ID

  • 25044548

Pubmed Central ID

  • 25044548

Electronic International Standard Serial Number (EISSN)

  • 1552-485X

Digital Object Identifier (DOI)

  • 10.1002/ajmg.b.32254

Language

  • eng

Conference Location

  • United States