Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
Journal Article
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
Full Text
Duke Authors
Cited Authors
- Ellinor, PT; Lunetta, KL; Albert, CM; Glazer, NL; Ritchie, MD; Smith, AV; Arking, DE; Müller-Nurasyid, M; Krijthe, BP; Lubitz, SA; Bis, JC; Chung, MK; Dörr, M; Ozaki, K; Roberts, JD; Smith, JG; Pfeufer, A; Sinner, MF; Lohman, K; Ding, J; Smith, NL; Smith, JD; Rienstra, M; Rice, KM; Van Wagoner, DR; Magnani, JW; Wakili, R; Clauss, S; Rotter, JI; Steinbeck, G; Launer, LJ; Davies, RW; Borkovich, M; Harris, TB; Lin, H; Völker, U; Völzke, H; Milan, DJ; Hofman, A; Boerwinkle, E; Chen, LY; Soliman, EZ; Voight, BF; Li, G; Chakravarti, A; Kubo, M; Tedrow, UB; Rose, LM; Ridker, PM; Conen, D; Tsunoda, T; Furukawa, T; Sotoodehnia, N; Xu, S; Kamatani, N; Levy, D; Nakamura, Y; Parvez, B; Mahida, S; Furie, KL; Rosand, J; Muhammad, R; Psaty, BM; Meitinger, T; Perz, S; Wichmann, H-E; Witteman, JCM; Kao, WHL; Kathiresan, S; Roden, DM; Uitterlinden, AG; Rivadeneira, F; McKnight, B; Sjögren, M; Newman, AB; Liu, Y; Gollob, MH; Melander, O; Tanaka, T; Stricker, BHC; Felix, SB; Alonso, A; Darbar, D; Barnard, J; Chasman, DI; Heckbert, SR; Benjamin, EJ; Gudnason, V; Kääb, S
Published Date
- April 29, 2012
Published In
Volume / Issue
- 44 / 6
Start / End Page
- 670 - 675
PubMed ID
- 22544366
Pubmed Central ID
- 22544366
Electronic International Standard Serial Number (EISSN)
- 1546-1718
Digital Object Identifier (DOI)
- 10.1038/ng.2261
Language
- eng
Conference Location
- United States