Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
Ellinor, PT; Lunetta, KL; Albert, CM; Glazer, NL; Ritchie, MD; Smith, AV; Arking, DE; Müller-Nurasyid, M; Krijthe, BP; Lubitz, SA; Bis, JC; Chung, MK; Dörr, M; Ozaki, K; Roberts, JD; Smith, JG; Pfeufer, A; Sinner, MF; Lohman, K; Ding, J; Smith, NL; Smith, JD; Rienstra, M; Rice, KM; Van Wagoner, DR; Magnani, JW; Wakili, R; Clauss, S; Rotter, JI; Steinbeck, G; Launer, LJ; Davies, RW; Borkovich, M; Harris, TB; Lin, H; Völker, U; Völzke, H; Milan, DJ; Hofman, A; Boerwinkle, E; Chen, LY; Soliman, EZ; Voight, BF; Li, G; Chakravarti, A; Kubo, M; Tedrow, UB; Rose, LM; Ridker, PM; Conen, D; Tsunoda, T; Furukawa, T; Sotoodehnia, N; Xu, S; Kamatani, N; Levy, D; Nakamura, Y; Parvez, B; Mahida, S; Furie, KL; Rosand, J; Muhammad, R; Psaty, BM; Meitinger, T; Perz, S; Wichmann, H-E; Witteman, JCM; Kao, WHL; Kathiresan, S; Roden, DM; Uitterlinden, AG; Rivadeneira, F; McKnight, B; Sjögren, M; Newman, AB; Liu, Y; Gollob, MH; Melander, O; Tanaka, T; Stricker, BHC; Felix, SB; Alonso, A; Darbar, D; Barnard, J; Chasman, DI; Heckbert, SR; Benjamin, EJ; Gudnason, V; Kääb, S
Volume / Issue
Start / End Page
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)