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Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

Publication ,  Journal Article
Ellinor, PT; Lunetta, KL; Albert, CM; Glazer, NL; Ritchie, MD; Smith, AV; Arking, DE; Müller-Nurasyid, M; Krijthe, BP; Lubitz, SA; Bis, JC ...
Published in: Nat Genet
April 29, 2012

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

April 29, 2012

Volume

44

Issue

6

Start / End Page

670 / 675

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Genome-Wide Association Study
 

Citation

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Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., … Kääb, S. (2012). Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet, 44(6), 670–675. https://doi.org/10.1038/ng.2261
Ellinor, Patrick T., Kathryn L. Lunetta, Christine M. Albert, Nicole L. Glazer, Marylyn D. Ritchie, Albert V. Smith, Dan E. Arking, et al. “Meta-analysis identifies six new susceptibility loci for atrial fibrillation.Nat Genet 44, no. 6 (April 29, 2012): 670–75. https://doi.org/10.1038/ng.2261.
Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012 Apr 29;44(6):670–5.
Ellinor, Patrick T., et al. “Meta-analysis identifies six new susceptibility loci for atrial fibrillation.Nat Genet, vol. 44, no. 6, Apr. 2012, pp. 670–75. Pubmed, doi:10.1038/ng.2261.
Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, Smith JG, Pfeufer A, Sinner MF, Lohman K, Ding J, Smith NL, Smith JD, Rienstra M, Rice KM, Van Wagoner DR, Magnani JW, Wakili R, Clauss S, Rotter JI, Steinbeck G, Launer LJ, Davies RW, Borkovich M, Harris TB, Lin H, Völker U, Völzke H, Milan DJ, Hofman A, Boerwinkle E, Chen LY, Soliman EZ, Voight BF, Li G, Chakravarti A, Kubo M, Tedrow UB, Rose LM, Ridker PM, Conen D, Tsunoda T, Furukawa T, Sotoodehnia N, Xu S, Kamatani N, Levy D, Nakamura Y, Parvez B, Mahida S, Furie KL, Rosand J, Muhammad R, Psaty BM, Meitinger T, Perz S, Wichmann H-E, Witteman JCM, Kao WHL, Kathiresan S, Roden DM, Uitterlinden AG, Rivadeneira F, McKnight B, Sjögren M, Newman AB, Liu Y, Gollob MH, Melander O, Tanaka T, Stricker BHC, Felix SB, Alonso A, Darbar D, Barnard J, Chasman DI, Heckbert SR, Benjamin EJ, Gudnason V, Kääb S. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012 Apr 29;44(6):670–675.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

April 29, 2012

Volume

44

Issue

6

Start / End Page

670 / 675

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Genome-Wide Association Study