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Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

Publication ,  Journal Article
Lettre, G; Palmer, CD; Young, T; Ejebe, KG; Allayee, H; Benjamin, EJ; Bennett, F; Bowden, DW; Chakravarti, A; Dreisbach, A; Farlow, DN; Fox, E ...
Published in: PLoS Genet
February 10, 2011

Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, and type-2 diabetes) in individuals of African ancestry, we performed a genome-wide association study (GWAS) in 8,090 African Americans from five population-based cohorts. We replicated 17 loci previously associated with CHD or its risk factors in Caucasians. For five of these regions (CHD: CDKN2A/CDKN2B; HDL-C: FADS1-3, PLTP, LPL, and ABCA1), we could leverage the distinct linkage disequilibrium (LD) patterns in African Americans to identify DNA polymorphisms more strongly associated with the phenotypes than the previously reported index SNPs found in Caucasian populations. We also developed a new approach for association testing in admixed populations that uses allelic and local ancestry variation. Using this method, we discovered several loci that would have been missed using the basic allelic and global ancestry information only. Our conclusions suggest that no major loci uniquely explain the high prevalence of CHD in African Americans. Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia.

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Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

February 10, 2011

Volume

7

Issue

2

Start / End Page

e1001300

Location

United States

Related Subject Headings

  • White People
  • United States
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Hypertension
  • Humans
  • Genome-Wide Association Study
  • Genome, Human
  • Developmental Biology
  • Delta-5 Fatty Acid Desaturase
 

Citation

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Chicago
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Lettre, G., Palmer, C. D., Young, T., Ejebe, K. G., Allayee, H., Benjamin, E. J., … Boerwinkle, E. (2011). Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet, 7(2), e1001300. https://doi.org/10.1371/journal.pgen.1001300
Lettre, Guillaume, Cameron D. Palmer, Taylor Young, Kenechi G. Ejebe, Hooman Allayee, Emelia J. Benjamin, Franklyn Bennett, et al. “Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.PLoS Genet 7, no. 2 (February 10, 2011): e1001300. https://doi.org/10.1371/journal.pgen.1001300.
Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, et al. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet. 2011 Feb 10;7(2):e1001300.
Lettre, Guillaume, et al. “Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.PLoS Genet, vol. 7, no. 2, Feb. 2011, p. e1001300. Pubmed, doi:10.1371/journal.pgen.1001300.
Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, Haiman CA, Hartiala J, Harris TB, Hazen SL, Heckbert SR, Henderson BE, Hirschhorn JN, Keating BJ, Kritchevsky SB, Larkin E, Li M, Rudock ME, McKenzie CA, Meigs JB, Meng YA, Mosley TH, Newman AB, Newton-Cheh CH, Paltoo DN, Papanicolaou GJ, Patterson N, Post WS, Psaty BM, Qasim AN, Qu L, Rader DJ, Redline S, Reilly MP, Reiner AP, Rich SS, Rotter JI, Liu Y, Shrader P, Siscovick DS, Tang WHW, Taylor HA, Tracy RP, Vasan RS, Waters KM, Wilks R, Wilson JG, Fabsitz RR, Gabriel SB, Kathiresan S, Boerwinkle E. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet. 2011 Feb 10;7(2):e1001300.

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

February 10, 2011

Volume

7

Issue

2

Start / End Page

e1001300

Location

United States

Related Subject Headings

  • White People
  • United States
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Hypertension
  • Humans
  • Genome-Wide Association Study
  • Genome, Human
  • Developmental Biology
  • Delta-5 Fatty Acid Desaturase