Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.

Journal Article (Journal Article)

OBJECTIVE: Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants. RESEARCH DESIGN AND METHODS: We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes. RESULTS: We observed a significant association of total zinc intake with lower fasting glucose levels (β-coefficient ± SE per 1 mg/day of zinc intake: -0.0012 ± 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant. CONCLUSIONS: Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels.

Full Text

Duke Authors

Cited Authors

  • Kanoni, S; Nettleton, JA; Hivert, M-F; Ye, Z; van Rooij, FJA; Shungin, D; Sonestedt, E; Ngwa, JS; Wojczynski, MK; Lemaitre, RN; Gustafsson, S; Anderson, JS; Tanaka, T; Hindy, G; Saylor, G; Renstrom, F; Bennett, AJ; van Duijn, CM; Florez, JC; Fox, CS; Hofman, A; Hoogeveen, RC; Houston, DK; Hu, FB; Jacques, PF; Johansson, I; Lind, L; Liu, Y; McKeown, N; Ordovas, J; Pankow, JS; Sijbrands, EJG; Syvänen, A-C; Uitterlinden, AG; Yannakoulia, M; Zillikens, MC; MAGIC Investigators, ; Wareham, NJ; Prokopenko, I; Bandinelli, S; Forouhi, NG; Cupples, LA; Loos, RJ; Hallmans, G; Dupuis, J; Langenberg, C; Ferrucci, L; Kritchevsky, SB; McCarthy, MI; Ingelsson, E; Borecki, IB; Witteman, JCM; Orho-Melander, M; Siscovick, DS; Meigs, JB; Franks, PW; Dedoussis, GV

Published Date

  • September 2011

Published In

Volume / Issue

  • 60 / 9

Start / End Page

  • 2407 - 2416

PubMed ID

  • 21810599

Pubmed Central ID

  • PMC3161318

Electronic International Standard Serial Number (EISSN)

  • 1939-327X

Digital Object Identifier (DOI)

  • 10.2337/db11-0176


  • eng

Conference Location

  • United States