Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?


Journal Article

Temozolomide (TMZ) is an alkylating agent used in the management of gliomas. Although TMZ is generally safe and acute toxicity is well documented, there are limited data on long-term toxicities. We present three patients with glioma; all patients started on TMZ after having progressed following primary treatment. These patients have continued TMZ for 5 years, 7 years and 8 years respectively. So far they have had no serious side effects. We discuss these patients while raising the question of prolonged TMZ use.

Full Text

Duke Authors

Cited Authors

  • Khasraw, M; Bell, D; Wheeler, H

Published Date

  • June 2009

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 854 - 855

PubMed ID

  • 19303779

Pubmed Central ID

  • 19303779

International Standard Serial Number (ISSN)

  • 0967-5868

Digital Object Identifier (DOI)

  • 10.1016/j.jocn.2008.09.005


  • eng

Conference Location

  • Scotland