Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data.

Journal Article (Review;Journal Article)

Chromosome conformation capture (3C) and its variants are powerful experimental techniques for probing intra- and inter-chromosomal interactions within cell nuclei at high resolution and in a high-throughput, quantitative manner. The contact maps derived from such experiments provide an avenue for inferring the 3D spatial organization of the genome. This review provides an overview of the various computational methods developed in the past decade for addressing the very important but challenging problem of deducing the detailed 3D structure or structure population of chromosomal domains, chromosomes, and even entire genomes from 3C contact maps.

Full Text

Duke Authors

Cited Authors

  • Meluzzi, D; Arya, G

Published Date

  • October 2020

Published In

Volume / Issue

  • 181-182 /

Start / End Page

  • 24 - 34

PubMed ID

  • 31470090

Pubmed Central ID

  • PMC7044057

Electronic International Standard Serial Number (EISSN)

  • 1095-9130

International Standard Serial Number (ISSN)

  • 1046-2023

Digital Object Identifier (DOI)

  • 10.1016/j.ymeth.2019.08.008


  • eng