Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data.
Published
Journal Article (Review)
Chromosome conformation capture (3C) and its variants are powerful experimental techniques for probing intra- and inter-chromosomal interactions within cell nuclei at high resolution and in a high-throughput, quantitative manner. The contact maps derived from such experiments provide an avenue for inferring the 3D spatial organization of the genome. This review provides an overview of the various computational methods developed in the past decade for addressing the very important but challenging problem of deducing the detailed 3D structure or structure population of chromosomal domains, chromosomes, and even entire genomes from 3C contact maps.
Full Text
Duke Authors
Cited Authors
- Meluzzi, D; Arya, G
Published Date
- October 2020
Published In
Volume / Issue
- 181-182 /
Start / End Page
- 24 - 34
PubMed ID
- 31470090
Pubmed Central ID
- 31470090
Electronic International Standard Serial Number (EISSN)
- 1095-9130
International Standard Serial Number (ISSN)
- 1046-2023
Digital Object Identifier (DOI)
- 10.1016/j.ymeth.2019.08.008
Language
- eng