APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It?

Published

Journal Article (Review)

Apolipoprotein L1 (APOL1) protein is the human serum factor that protect human beings against Trypanosoma brucei brucei, the cause of trypanosomiasis. Subspecies of T b brucei that cause human sleeping sickness-T b gambiense and T b rhodesiense evolved molecular mechanisms that enabled them to evade killing by APOL1. Sequence changes (termed G1 and G2) in the APOL1 gene that restored its ability to kill T b rhodesiense also increase the risk of developing glomerular diseases and accelerate progression to end-stage kidney disease. To lyse trypanosome parasites, APOL1 forms pores in the trypanosome endolysosomal and mitochondrial membranes, resulting in rapid membrane depolarization. However, the molecular mechanism underlying APOL1 nephropathy is unknown. Recent experimental evidence has shown that aberrant efflux of intracellular potassium is an early event in APOL1-induced death of human embryonic kidney cells. Here, we discuss the possibility that abnormal efflux of cellular potassium or other cations may be relevant to the pathogenesis of APOL1 nephropathy.

Full Text

Duke Authors

Cited Authors

  • Olabisi, OA; Heneghan, JF

Published Date

  • November 2017

Published In

Volume / Issue

  • 37 / 6

Start / End Page

  • 546 - 551

PubMed ID

  • 29110762

Pubmed Central ID

  • 29110762

Electronic International Standard Serial Number (EISSN)

  • 1558-4488

Digital Object Identifier (DOI)

  • 10.1016/j.semnephrol.2017.07.008

Language

  • eng

Conference Location

  • United States