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S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.

Publication ,  Journal Article
Maron, BA; Tang, S-S; Loscalzo, J
Published in: Antioxid Redox Signal
January 20, 2013

SIGNIFICANCE: Since their discovery in the early 1990's, S-nitrosylated proteins have been increasingly recognized as important determinants of many biochemical processes. Specifically, S-nitrosothiols in the cardiovascular system exert many actions, including promoting vasodilation, inhibiting platelet aggregation, and regulating Ca(2+) channel function that influences myocyte contractility and electrophysiologic stability. RECENT ADVANCES: Contemporary developments in liquid chromatography-mass spectrometry methods, the development of biotin- and His-tag switch assays, and the availability of cyanide dye-labeling for S-nitrosothiol detection in vitro have increased significantly the identification of a number of cardiovascular protein targets of S-nitrosylation in vivo. CRITICAL ISSUES: Recent analyses using modern S-nitrosothiol detection techniques have revealed the mechanistic significance of S-nitrosylation to the pathophysiology of numerous cardiovascular diseases, including essential hypertension, pulmonary hypertension, ischemic heart disease, stroke, and congestive heart failure, among others. FUTURE DIRECTIONS: Despite enhanced insight into S-nitrosothiol biochemistry, translating these advances into beneficial pharmacotherapies for patients with cardiovascular diseases remains a primary as-yet unmet goal for investigators within the field.

Duke Scholars

Published In

Antioxid Redox Signal

DOI

EISSN

1557-7716

Publication Date

January 20, 2013

Volume

18

Issue

3

Start / End Page

270 / 287

Location

United States

Related Subject Headings

  • S-Nitrosothiols
  • Proteome
  • Protein Processing, Post-Translational
  • Oxidation-Reduction
  • Nitrosation
  • Nitric Oxide
  • Humans
  • Glutathione
  • Cysteine
  • Cardiovascular System
 

Citation

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Maron, B. A., Tang, S.-S., & Loscalzo, J. (2013). S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. Antioxid Redox Signal, 18(3), 270–287. https://doi.org/10.1089/ars.2012.4744
Maron, Bradley A., Shiow-Shih Tang, and Joseph Loscalzo. “S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.Antioxid Redox Signal 18, no. 3 (January 20, 2013): 270–87. https://doi.org/10.1089/ars.2012.4744.
Maron BA, Tang S-S, Loscalzo J. S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. Antioxid Redox Signal. 2013 Jan 20;18(3):270–87.
Maron, Bradley A., et al. “S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.Antioxid Redox Signal, vol. 18, no. 3, Jan. 2013, pp. 270–87. Pubmed, doi:10.1089/ars.2012.4744.
Maron BA, Tang S-S, Loscalzo J. S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. Antioxid Redox Signal. 2013 Jan 20;18(3):270–287.
Journal cover image

Published In

Antioxid Redox Signal

DOI

EISSN

1557-7716

Publication Date

January 20, 2013

Volume

18

Issue

3

Start / End Page

270 / 287

Location

United States

Related Subject Headings

  • S-Nitrosothiols
  • Proteome
  • Protein Processing, Post-Translational
  • Oxidation-Reduction
  • Nitrosation
  • Nitric Oxide
  • Humans
  • Glutathione
  • Cysteine
  • Cardiovascular System