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Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications.

Publication ,  Journal Article
Zander, ZK; Chen, P; Hsu, Y-H; Dreger, NZ; Savariau, L; McRoy, WC; Cerchiari, AE; Chambers, SD; Barton, HA; Becker, ML
Published in: Biomaterials
September 2018

The use of catheters is ubiquitous in medicine and the incidence of infection remains unacceptably high despite numerous advances in functional surfaces and drug elution. Herein we report the use of a thermoplastic polyurethane containing an allyl ether side-chain functionality (allyl-TPU) that allows for rapid and convenient surface modification with antimicrobial reagents, post-processing. This post-processing functionalization affords the ability to target appropriate TPU properties and maintain the functional groups on the surface of the device where they do not affect bulk properties. A series of quaternary ammonium thiol compounds (Qx-SH) possessing various hydrocarbon tail lengths (8-14 carbons) were synthesized and attached to the surface using thiol-ene "click" chemistry. A quantitative assessment of the amount of Qx-SH available on the surface was determined using fluorescence spectroscopy and X-ray photoelectron spectroscopy (XPS). Contact-killing assays note the Q8-SH composition has the highest antimicrobial activity, and a live/dead fluorescence assay reveals rapid contact-killing of Staphylococcus aureus (>75% in 5 min) and Escherichia coli (90% in 10 min) inocula. Scale-up and extrusion of allyl-TPU provides catheter prototypes for biofilm formation testing with Pseudomonas aeruginosa, and surface-functionalized catheters modified with Q8-SH demonstrate their ability to reduce biofilm formation.

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Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

September 2018

Volume

178

Start / End Page

339 / 350

Related Subject Headings

  • Temperature
  • Surface Properties
  • Sulfhydryl Compounds
  • Quaternary Ammonium Compounds
  • Polyurethanes
  • Plastics
  • Photoelectron Spectroscopy
  • NIH 3T3 Cells
  • Microbial Viability
  • Microbial Sensitivity Tests
 

Citation

APA
Chicago
ICMJE
MLA
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Zander, Z. K., Chen, P., Hsu, Y.-H., Dreger, N. Z., Savariau, L., McRoy, W. C., … Becker, M. L. (2018). Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. Biomaterials, 178, 339–350. https://doi.org/10.1016/j.biomaterials.2018.05.010
Zander, Zachary K., Peiru Chen, Yen-Hao Hsu, Nathan Z. Dreger, Laura Savariau, Willie C. McRoy, Alec E. Cerchiari, Sean D. Chambers, Hazel A. Barton, and Matthew L. Becker. “Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications.Biomaterials 178 (September 2018): 339–50. https://doi.org/10.1016/j.biomaterials.2018.05.010.
Zander ZK, Chen P, Hsu Y-H, Dreger NZ, Savariau L, McRoy WC, et al. Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. Biomaterials. 2018 Sep;178:339–50.
Zander, Zachary K., et al. “Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications.Biomaterials, vol. 178, Sept. 2018, pp. 339–50. Epmc, doi:10.1016/j.biomaterials.2018.05.010.
Zander ZK, Chen P, Hsu Y-H, Dreger NZ, Savariau L, McRoy WC, Cerchiari AE, Chambers SD, Barton HA, Becker ML. Post-fabrication QAC-functionalized thermoplastic polyurethane for contact-killing catheter applications. Biomaterials. 2018 Sep;178:339–350.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

September 2018

Volume

178

Start / End Page

339 / 350

Related Subject Headings

  • Temperature
  • Surface Properties
  • Sulfhydryl Compounds
  • Quaternary Ammonium Compounds
  • Polyurethanes
  • Plastics
  • Photoelectron Spectroscopy
  • NIH 3T3 Cells
  • Microbial Viability
  • Microbial Sensitivity Tests