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Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair.

Publication ,  Journal Article
Wade, MB; Rodenberg, E; Patel, U; Shah, B; Becker, ML
Published in: Biomacromolecules
October 2016

Degradable poly(ester urea)s (PEU)s were electrospun into nanofiber sheets and assessed for their potential to be used in soft tissue repair. The level of residual solvent was measured and the effects of ethylene oxide and electron beam sterilization techniques on molecular mass, mass distribution, and morphology were quantified. Two PEU compositions that formed stable nanofiber sheets were advanced into a pilot study in vitro and in vivo as candidate materials for hernia repair. Cell viability, spreading, proliferation, and migration were examined in vitro. Nanofiber sheets were implanted subcutaneously into mice and analyzed via microangiography and histology for tissue incorporation. Nanofiber sheets performed similarly to decellularized extracellular matrix (ECM) in vitro, but the lack of sufficient pore structure inhibited cellular infiltration after 14 days of culture. The lack of microporous features in nanofiber sheets also contributed to low levels of cellular infiltration, angiogenesis, and matrix deposition in vivo. A preliminary study to increase pore size in nanofibers was performed using coaxial electrospinning resulting in significant improvement in tissue infiltration in vivo.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

October 2016

Volume

17

Issue

10

Start / End Page

3363 / 3374

Related Subject Headings

  • Urea
  • Tissue Scaffolds
  • Tissue Engineering
  • Sterilization
  • Polymers
  • Polyesters
  • Nanofibers
  • Humans
  • Herniorrhaphy
  • Hernia
 

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ICMJE
MLA
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Wade, M. B., Rodenberg, E., Patel, U., Shah, B., & Becker, M. L. (2016). Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair. Biomacromolecules, 17(10), 3363–3374. https://doi.org/10.1021/acs.biomac.6b01158
Wade, Mary Beth, Eric Rodenberg, Umesh Patel, Bhavin Shah, and Matthew L. Becker. “Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair.Biomacromolecules 17, no. 10 (October 2016): 3363–74. https://doi.org/10.1021/acs.biomac.6b01158.
Wade MB, Rodenberg E, Patel U, Shah B, Becker ML. Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair. Biomacromolecules. 2016 Oct;17(10):3363–74.
Wade, Mary Beth, et al. “Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair.Biomacromolecules, vol. 17, no. 10, Oct. 2016, pp. 3363–74. Epmc, doi:10.1021/acs.biomac.6b01158.
Wade MB, Rodenberg E, Patel U, Shah B, Becker ML. Influence of Sterilization Technologies on Electrospun Poly(ester urea)s for Soft Tissue Repair. Biomacromolecules. 2016 Oct;17(10):3363–3374.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

October 2016

Volume

17

Issue

10

Start / End Page

3363 / 3374

Related Subject Headings

  • Urea
  • Tissue Scaffolds
  • Tissue Engineering
  • Sterilization
  • Polymers
  • Polyesters
  • Nanofibers
  • Humans
  • Herniorrhaphy
  • Hernia