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Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds.

Publication ,  Journal Article
Luo, Y; Dolder, CK; Walker, JM; Mishra, R; Dean, D; Becker, ML
Published in: Biomacromolecules
February 2016

A ring opening polymerization method for synthesizing oligomeric poly(propylene fumarate) (PPF) provides a rapid, and scalable method of synthesizing PPF with well-defined molecular mass, molecular mass distribution (Đm), and viscosity properties suitable for 3D printing. These properties will also reduce the amount of solvent necessary to ensure sufficient flow of material during 3D printing. MALDI mass spectrometry precisely shows the end group fidelity, and size exclusion chromatography (SEC) demonstrates narrow mass distributions (<1.6) of a series of low molecular mass oligomers (700-3000 Da). The corresponding intrinsic viscosities range from 0.0288 ± 0.0009 dL/g to 0.0780 ± 0.0022 dL/g. The oligomers were printed into scaffolds via established photochemical methods and standardized ISO 10993-5 testing shows that the 3D printed materials are nontoxic to both L929 mouse fibroblasts and human mesenchymal stem cells.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2016

Volume

17

Issue

2

Start / End Page

690 / 697

Related Subject Headings

  • Tissue Scaffolds
  • Porosity
  • Polypropylenes
  • Polymers
  • Mice
  • Mesenchymal Stem Cells
  • Materials Testing
  • Humans
  • Fumarates
  • Cell Survival
 

Citation

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ICMJE
MLA
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Luo, Y., Dolder, C. K., Walker, J. M., Mishra, R., Dean, D., & Becker, M. L. (2016). Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds. Biomacromolecules, 17(2), 690–697. https://doi.org/10.1021/acs.biomac.6b00014
Luo, Yuanyuan, Courtney K. Dolder, Jason M. Walker, Ruchi Mishra, David Dean, and Matthew L. Becker. “Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds.Biomacromolecules 17, no. 2 (February 2016): 690–97. https://doi.org/10.1021/acs.biomac.6b00014.
Luo Y, Dolder CK, Walker JM, Mishra R, Dean D, Becker ML. Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds. Biomacromolecules. 2016 Feb;17(2):690–7.
Luo, Yuanyuan, et al. “Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds.Biomacromolecules, vol. 17, no. 2, Feb. 2016, pp. 690–97. Epmc, doi:10.1021/acs.biomac.6b00014.
Luo Y, Dolder CK, Walker JM, Mishra R, Dean D, Becker ML. Synthesis and Biological Evaluation of Well-Defined Poly(propylene fumarate) Oligomers and Their Use in 3D Printed Scaffolds. Biomacromolecules. 2016 Feb;17(2):690–697.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2016

Volume

17

Issue

2

Start / End Page

690 / 697

Related Subject Headings

  • Tissue Scaffolds
  • Porosity
  • Polypropylenes
  • Polymers
  • Mice
  • Mesenchymal Stem Cells
  • Materials Testing
  • Humans
  • Fumarates
  • Cell Survival