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Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s.

Publication ,  Journal Article
Li, S; Yu, J; Wade, MB; Policastro, GM; Becker, ML
Published in: Biomacromolecules
February 2015

The synthesis and characterization of iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) are reported. 4-Iodo-L-phenylalanine and L-phenylalanine were separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). By varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition was modulated resulting in a wide variation in thermal, mechanical and radiopacity properties. Microcomputed tomography (μ-CT) projections demonstrate that increasing iodine content results in greater X-ray contrast. Compression tests of dry and wet porous scaffolds indicate that the poly(1-IPHE-6)0.24-co-poly(1-PHE-6)0.76 material results in the highest compression modulus. MC3T3 cell viability and spreading studies show PEUs are nontoxic to cells. As most medical device procedures require placement verification via fluoroscopic imaging, materials that possess inherent X-ray contrast are valuable for a number of applications.

Duke Scholars

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2015

Volume

16

Issue

2

Start / End Page

615 / 624

Related Subject Headings

  • Urea
  • Polymers
  • Polyesters
  • Phenylalanine
  • NIH 3T3 Cells
  • Mice
  • Contrast Media
  • Cell Survival
  • Animals
  • 40 Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, S., Yu, J., Wade, M. B., Policastro, G. M., & Becker, M. L. (2015). Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s. Biomacromolecules, 16(2), 615–624. https://doi.org/10.1021/bm501669u
Li, Shan, Jiayi Yu, Mary Beth Wade, Gina M. Policastro, and Matthew L. Becker. “Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s.Biomacromolecules 16, no. 2 (February 2015): 615–24. https://doi.org/10.1021/bm501669u.
Li S, Yu J, Wade MB, Policastro GM, Becker ML. Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s. Biomacromolecules. 2015 Feb;16(2):615–24.
Li, Shan, et al. “Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s.Biomacromolecules, vol. 16, no. 2, Feb. 2015, pp. 615–24. Epmc, doi:10.1021/bm501669u.
Li S, Yu J, Wade MB, Policastro GM, Becker ML. Radiopaque, iodine functionalized, phenylalanine-based poly(ester urea)s. Biomacromolecules. 2015 Feb;16(2):615–624.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2015

Volume

16

Issue

2

Start / End Page

615 / 624

Related Subject Headings

  • Urea
  • Polymers
  • Polyesters
  • Phenylalanine
  • NIH 3T3 Cells
  • Mice
  • Contrast Media
  • Cell Survival
  • Animals
  • 40 Engineering