Enhanced Schwann cell attachment and alignment using one-pot "dual click" GRGDS and YIGSR derivatized nanofibers.

Journal Article (Journal Article)

Using metal-free click chemistry and oxime condensation methodologies, GRGDS and YIGSR peptides were coupled to random and aligned degradable nanofiber networks postelectrospinning in a one-pot reaction. The bound peptides are bioactive, as demonstrated by Schwann cell attachment and proliferation, and the inclusion of YIGSR with GRGDS alters the expression of the receptor for YIGSR. Additionally, aligned nanofibers act as a potential guidance cue by increasing the aspect ratio and aligning the actin filaments, which suggest that peptide-functionalized scaffolds would be useful to direct SCs for peripheral nerve regeneration.

Full Text

Duke Authors

Cited Authors

  • Zheng, J; Kontoveros, D; Lin, F; Hua, G; Reneker, DH; Becker, ML; Willits, RK

Published Date

  • January 2015

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 357 - 363

PubMed ID

  • 25479181

Pubmed Central ID

  • PMC5953569

Electronic International Standard Serial Number (EISSN)

  • 1526-4602

International Standard Serial Number (ISSN)

  • 1525-7797

Digital Object Identifier (DOI)

  • 10.1021/bm501552t


  • eng