Green polymer chemistry VIII: synthesis of halo-ester-functionalized poly(ethylene glycol)s via enzymatic catalysis.

Journal Article (Journal Article)

Halo-ester-functionalized poly(ethylene glycol)s (PEGs) are successfully prepared by the transesterification of alkyl halo-esters with PEGs using Candida antarctica lipase B (CALB) as a biocatalyst under the solventless conditions. Transesterifications of chlorine, bromine, and iodine esters with tetraethylene glycol monobenzyl ether (BzTEG) are quantitative in less than 2.5 h. The transesterification of halo-esters with PEGs are complete in 4 h. (1) H and (13) C NMR spectroscopy with MALDI-ToF and ESI mass spectrometry confirm the structure and purity of the products. This method provides a convenient and "green" process to effectively produce halo-ester PEGs.

Full Text

Duke Authors

Cited Authors

  • Castano, M; Seo, KS; Kim, EH; Becker, ML; Puskas, JE

Published Date

  • September 2013

Published In

Volume / Issue

  • 34 / 17

Start / End Page

  • 1375 - 1380

PubMed ID

  • 23877930

Electronic International Standard Serial Number (EISSN)

  • 1521-3927

International Standard Serial Number (ISSN)

  • 1022-1336

Digital Object Identifier (DOI)

  • 10.1002/marc.201300430


  • eng