Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.
Journal Article (Journal Article)
A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.
Full Text
Duke Authors
Cited Authors
- Zheng, J; Liu, K; Reneker, DH; Becker, ML
Published Date
- October 2012
Published In
Volume / Issue
- 134 / 41
Start / End Page
- 17274 - 17277
PubMed ID
- 23013452
Electronic International Standard Serial Number (EISSN)
- 1520-5126
International Standard Serial Number (ISSN)
- 0002-7863
Digital Object Identifier (DOI)
- 10.1021/ja307647x
Language
- eng