Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.

Published

Journal Article

A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.

Full Text

Duke Authors

Cited Authors

  • Zheng, J; Liu, K; Reneker, DH; Becker, ML

Published Date

  • October 8, 2012

Published In

Volume / Issue

  • 134 / 41

Start / End Page

  • 17274 - 17277

PubMed ID

  • 23013452

Pubmed Central ID

  • 23013452

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja307647x

Language

  • eng