Strain-promoted cross-linking of PEG-based hydrogels via copper- free cycloaddition
The synthesis of a 4-dibenzocyclooctynol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain-promoted, metal-free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross-linking mechanisms. © 2012 American Chemical Society.
Zheng, J; Smith Callahan, LA; Hao, J; Guo, K; Wesdemiotis, C; Weiss, RA; Becker, ML
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