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The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces.

Publication ,  Journal Article
Yu, J; Becker, ML; Carri, GA
Published in: Langmuir : the ACS journal of surfaces and colloids
January 2012

We present a molecular dynamics study of the binding process of peptide A3 (AYSSGAPPMPPF) and other similar peptides onto gold surfaces, and identify the functions of many amino acids. Our results provide a clear picture of the separate regimes present in the binding process: diffusion, anchoring, crawling and binding. Moreover, we explored the roles of individual residues. We found that tyrosine, methionine, and phenylalanine are strong binding residues; serine serves as an effective anchoring residue; proline acts as a dynamic anchoring point, while glycine and alanine give flexibility to the peptide backbone. We then show that our findings apply to unrelated phage-derived sequences that have been reported recently to facilitate AuNP synthesis. This new knowledge may aid in the design of new peptides for the synthesis of gold nanostructures with novel morphologies.

Duke Scholars

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

January 2012

Volume

28

Issue

2

Start / End Page

1408 / 1417

Related Subject Headings

  • Surface Properties
  • Peptides
  • Gold
  • Chemical Physics
  • Amino Acids
  • Amino Acid Sequence
 

Citation

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MLA
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Yu, J., Becker, M. L., & Carri, G. A. (2012). The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces. Langmuir : The ACS Journal of Surfaces and Colloids, 28(2), 1408–1417. https://doi.org/10.1021/la204109r
Yu, Jing, Matthew L. Becker, and Gustavo A. Carri. “The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces.Langmuir : The ACS Journal of Surfaces and Colloids 28, no. 2 (January 2012): 1408–17. https://doi.org/10.1021/la204109r.
Yu J, Becker ML, Carri GA. The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces. Langmuir : the ACS journal of surfaces and colloids. 2012 Jan;28(2):1408–17.
Yu, Jing, et al. “The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces.Langmuir : The ACS Journal of Surfaces and Colloids, vol. 28, no. 2, Jan. 2012, pp. 1408–17. Epmc, doi:10.1021/la204109r.
Yu J, Becker ML, Carri GA. The influence of amino acid sequence and functionality on the binding process of peptides onto gold surfaces. Langmuir : the ACS journal of surfaces and colloids. 2012 Jan;28(2):1408–1417.
Journal cover image

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

January 2012

Volume

28

Issue

2

Start / End Page

1408 / 1417

Related Subject Headings

  • Surface Properties
  • Peptides
  • Gold
  • Chemical Physics
  • Amino Acids
  • Amino Acid Sequence