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Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D

Publication ,  Journal Article
Yang, Y; Bolikal, D; Becker, ML; Kohn, J; Zeiger, DN; Simon, CG
Published in: Advanced Materials
June 4, 2008

A method for fabricating combinatorial libraries of polymer scaffolds was proposed for screening cell-biomaterial interactions in a three-dimensional (3D) format. The libraries used were of varying composition of two amorphous, biodegradable, biocompatible, tyrosine-derived polycarbonates, namely, pDTEc [poly(desaminotyrosyl-tyrosine ethyl ester carbonate)] and pDTOc [poly(desaminotyrosyl-tyrosine octyl ester carbonate)]. The fabrication of combinatorial libraries was made in polypropylene 96-well plates using a two-syirnge pump system, yielding arrays of salt-leached, macroporous scaffolds of varying compositions of pDTEc and pDTOc, having different physiochemical properties. The designed libraries were ideal for screening cell response so that scaffold formulations that promote or suppress cellular activity can be identified rapidly.

Duke Scholars

Published In

Advanced Materials

DOI

ISSN

0935-9648

Publication Date

June 4, 2008

Volume

20

Issue

11

Start / End Page

2037 / 2043

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

Citation

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ICMJE
MLA
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Yang, Y., Bolikal, D., Becker, M. L., Kohn, J., Zeiger, D. N., & Simon, C. G. (2008). Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D. Advanced Materials, 20(11), 2037–2043. https://doi.org/10.1002/adma.200702088
Yang, Y., D. Bolikal, M. L. Becker, J. Kohn, D. N. Zeiger, and C. G. Simon. “Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D.” Advanced Materials 20, no. 11 (June 4, 2008): 2037–43. https://doi.org/10.1002/adma.200702088.
Yang Y, Bolikal D, Becker ML, Kohn J, Zeiger DN, Simon CG. Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D. Advanced Materials. 2008 Jun 4;20(11):2037–43.
Yang, Y., et al. “Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D.” Advanced Materials, vol. 20, no. 11, June 2008, pp. 2037–43. Scopus, doi:10.1002/adma.200702088.
Yang Y, Bolikal D, Becker ML, Kohn J, Zeiger DN, Simon CG. Combinatorial polymer scaffold libraries for screening cell-biomaterial interactions in 3D. Advanced Materials. 2008 Jun 4;20(11):2037–2043.
Journal cover image

Published In

Advanced Materials

DOI

ISSN

0935-9648

Publication Date

June 4, 2008

Volume

20

Issue

11

Start / End Page

2037 / 2043

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences