Cancer vaccines in colon and rectal cancer over the last decade: lessons learned and future directions.

Published

Journal Article (Review)

INTRODUCTION: Great advances have been made in screening for and treatment of colorectal cancer (CRC), but recurrence rates remain high and additional therapies are needed. There is great excitement around the field of immunotherapy and many attempts have been made to bring immunotherapy to CRC through a cancer vaccine. Areas covered: This is a detailed review of the last decade's significant CRC vaccine trials. Expert commentary: Monotherapy with a CRC vaccine is likely best suited for adjuvant therapy in disease free patients. Vaccine therapy elicits crucial tumor infiltrating lymphocytes, which are lacking in microsatellite-stable tumors, and therefore may be better suited for these patients. The combination of CRC vaccines with checkpoint inhibitors may unlock the potential of immunotherapy for a much broader range of patients. Future studies should focus on vaccine monotherapy in correctly selected patients and combination therapy in more advanced disease.

Full Text

Duke Authors

Cited Authors

  • Berry, J; Vreeland, T; Trappey, A; Hale, D; Peace, K; Tyler, J; Walker, A; Brown, R; Herbert, G; Yi, F; Jackson, D; Clifton, G; Peoples, GE

Published Date

  • March 2017

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 235 - 245

PubMed ID

  • 27552944

Pubmed Central ID

  • 27552944

Electronic International Standard Serial Number (EISSN)

  • 1744-8409

Digital Object Identifier (DOI)

  • 10.1080/1744666X.2016.1226132

Language

  • eng

Conference Location

  • England