Topical Review: Use of Fetal Tissue in Foot and Ankle Surgery.

Journal Article (Journal Article;Review)

UNLABELLED: Fetal tissues are well known for their therapeutic potential. They contain numerous growth factors, cytokines, and matrix components that promote regeneration of tissues while downregulating inflammation and scar formation. As a result, use of these treatments has expanded over the previous 20 years throughout various surgical specialties, including orthopaedics. With improved methods of sterilization, processing, and storage, surgeons need to be informed about the potential benefits of fetal tissue in foot and ankle surgery. The aim of this review is to provide a brief historical background, basic anatomy and physiology, and a current review of the literature in regard to chronic wounds, diabetic foot ulcerations, plantar fasciitis, tendon repair, adhesion prevention, nerve repair, and bone healing. LEVELS OF EVIDENCE: Level V: Expert Opinion.

Full Text

Duke Authors

Cited Authors

  • Hanselman, AE; Lalli, TAJ; Santrock, RD

Published Date

  • August 2015

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 297 - 304

PubMed ID

  • 25813778

Electronic International Standard Serial Number (EISSN)

  • 1938-7636

Digital Object Identifier (DOI)

  • 10.1177/1938640015578513


  • eng

Conference Location

  • United States