Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review.


Journal Article (Review)

BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. To prevent what will certainly be a tremendous health and economic burden, effective therapeutics for AMD are urgently needed. To develop these agents in a timely fashion, the molecular pathways that cause disease progression must be elucidated. OBJECTIVE: To briefly describe the clinical features of AMD, and review the current understanding of the molecular basis of AMD. METHODS: A literature review. RESULTS: The discussion will primarily focus on the interplay of oxidative stress and complement dysregulation and the resulting chronic proinflammatory state thought to be central in AMD pathogenesis. CONCLUSIONS: Oxidative stress and complement dysregulation play a substantive role in the development of AMD.

Full Text

Duke Authors

Cited Authors

  • Barnett, BP; Handa, JT

Published Date

  • 2013

Published In

Volume / Issue

  • 59 / 4

Start / End Page

  • 297 - 306

PubMed ID

  • 23406680

Pubmed Central ID

  • 23406680

Electronic International Standard Serial Number (EISSN)

  • 1423-0003

Digital Object Identifier (DOI)

  • 10.1159/000346169


  • eng

Conference Location

  • Switzerland