αB-crystallin negative astrocytic inclusions.

Published

Journal Article

We report on an unusual pathological finding of astrocytes, observed in the brain of a 16-year-old African-American male with severe intellectual disability and spastic quadriplegia. The brain showed bilateral pericentral, perisylvian polymicrogyria and pachygyria, in conjunction with a large number of hypertrophic astrocytes with eosinophilic granular cytoplasmic inclusions. The astrocytic abnormality was more severe in the dysgenetic area but present throughout the cerebral cortex. Astrocytic inclusions stained with acid fuchsin, azocarmine and Holzer's stain, and were immunoreactive for GFAP, S-100, and ubiquitin, but not for αB-crystallin, filamin, vimentin, nestin, tau or α-synuclein. Based on the case and a review of the literature, the authors postulate that these astrocytic inclusions in the cerebral cortex reflect abnormalities in radial glial developmental processes, such as migration, differentiation, or glial-neuronal interaction function during neuronal migration.

Full Text

Duke Authors

Cited Authors

  • Barnett, BP; Bressler, J; Chen, T; Hutchins, GM; Crain, BJ; Kaufmann, WE

Published Date

  • April 2011

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 349 - 352

PubMed ID

  • 20621427

Pubmed Central ID

  • 20621427

Electronic International Standard Serial Number (EISSN)

  • 1872-7131

Digital Object Identifier (DOI)

  • 10.1016/j.braindev.2010.06.013

Language

  • eng

Conference Location

  • Netherlands