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In vitro assessment of EmboGel and UltraGel radiopaque hydrogels for the endovascular treatment of aneurysms.

Publication ,  Journal Article
Barnett, BP; Hughes, AH; Lin, S; Arepally, A; Gailloud, PH
Published in: Journal of vascular and interventional radiology : JVIR
April 2009

To describe two hydrogel embolic materials, the alginate-based EmboGel and the polyethylene glycol diacrylate-based UltraGel and examine their use as embolic agents in in vitro models of abdominal aortic aneurysm (AAA) endoleak and saccular aneurysms.EmboGel is a mixture of iohexol and alginate, with a calcium chloride solution used to induce polymerization. UltraGel is a mixture of igracure, iohexol, and polyethylene glycol diacrylate and polymerizes in the presence of ultraviolet (UV) light. Modified microcatheter delivery systems were used in both cases to demonstrate use of the hydrogels in fusiform and saccular aneurysm models.Preliminary in vitro results suggest that EmboGel and UltraGel provide effective embolization in fusiform and saccular aneurysm models, respectively. Due to the rapid polymerization of EmboGel, the agent was delivered in a strand-like form. When used in conjunction with a stent in an AAA endoleak model, this form was able to effectively fill the aneurysmal cavity and occlude it from the central blood flow. UltraGel, conversely, was delivered as a liquid and slowly polymerized in the presence of UV light. This system in a saccular aneurysm model was able to form a solid cast inside the aneurysm wall, again showing complete occlusion from the parent flow.Preliminary results indicate these two novel hydrogel applications may prove effective for the treatment of saccular and fusiform aneurysms.

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Published In

Journal of vascular and interventional radiology : JVIR

DOI

EISSN

1535-7732

ISSN

1051-0443

Publication Date

April 2009

Volume

20

Issue

4

Start / End Page

507 / 512

Related Subject Headings

  • Treatment Outcome
  • Radiography
  • Polyethylene Glycols
  • Nuclear Medicine & Medical Imaging
  • Iohexol
  • Humans
  • Gels
  • Fibrinolytic Agents
  • Embolization, Therapeutic
  • Drug Combinations
 

Citation

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Barnett, B. P., Hughes, A. H., Lin, S., Arepally, A., & Gailloud, P. H. (2009). In vitro assessment of EmboGel and UltraGel radiopaque hydrogels for the endovascular treatment of aneurysms. Journal of Vascular and Interventional Radiology : JVIR, 20(4), 507–512. https://doi.org/10.1016/j.jvir.2009.01.005
Barnett, Brad P., Andrew H. Hughes, Sopo Lin, Aravind Arepally, and Philippe H. Gailloud. “In vitro assessment of EmboGel and UltraGel radiopaque hydrogels for the endovascular treatment of aneurysms.Journal of Vascular and Interventional Radiology : JVIR 20, no. 4 (April 2009): 507–12. https://doi.org/10.1016/j.jvir.2009.01.005.
Barnett BP, Hughes AH, Lin S, Arepally A, Gailloud PH. In vitro assessment of EmboGel and UltraGel radiopaque hydrogels for the endovascular treatment of aneurysms. Journal of vascular and interventional radiology : JVIR. 2009 Apr;20(4):507–12.
Barnett, Brad P., et al. “In vitro assessment of EmboGel and UltraGel radiopaque hydrogels for the endovascular treatment of aneurysms.Journal of Vascular and Interventional Radiology : JVIR, vol. 20, no. 4, Apr. 2009, pp. 507–12. Epmc, doi:10.1016/j.jvir.2009.01.005.
Barnett BP, Hughes AH, Lin S, Arepally A, Gailloud PH. In vitro assessment of EmboGel and UltraGel radiopaque hydrogels for the endovascular treatment of aneurysms. Journal of vascular and interventional radiology : JVIR. 2009 Apr;20(4):507–512.
Journal cover image

Published In

Journal of vascular and interventional radiology : JVIR

DOI

EISSN

1535-7732

ISSN

1051-0443

Publication Date

April 2009

Volume

20

Issue

4

Start / End Page

507 / 512

Related Subject Headings

  • Treatment Outcome
  • Radiography
  • Polyethylene Glycols
  • Nuclear Medicine & Medical Imaging
  • Iohexol
  • Humans
  • Gels
  • Fibrinolytic Agents
  • Embolization, Therapeutic
  • Drug Combinations