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Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy.

Publication ,  Journal Article
Singh, T; Lopez, CA; Giuberti, C; Dennis, ML; Itell, HL; Heimsath, HJ; Webster, HS; Roark, HK; Merçon de Vargas, PR; Hall, A; Corey, RG ...
Published in: PLoS Negl Trop Dis
August 2019

Zika virus (ZIKV) is a newly-identified infectious cause of congenital disease. Transplacental transfer of maternal IgG to the fetus plays an important role in preventing many neonatal infections. However, antibody transfer may also have negative consequences, such as mediating enhancement of flavivirus infections in early life, or trafficking of virus immune complexes to the fetal compartment. ZIKV infection produces placental pathology which could lead to impaired IgG transfer efficiency as occurs in other maternal infections, such as HIV-1 and malaria. In this study, we asked whether ZIKV infection during pregnancy impairs transplacental transfer of IgG. We enrolled pregnant women with fever or rash in a prospective cohort in Vitoria, Brazil during the recent ZIKV epidemic. ZIKV and dengue virus (DENV)-specific IgG, ZIKV and DENV neutralizing antibodies, and routine vaccine antigen-specific IgG were measured in maternal samples collected around delivery and 20 paired cord blood samples. We concluded that 8 of these mothers were infected with ZIKV during pregnancy and 12 were ZIKV-uninfected. The magnitude of flavivirus-specific IgG, neutralizing antibody, and vaccine-elicited IgG were highly correlated between maternal plasma and infant cord blood in both ZIKV-infected and -uninfected mother-infant pairs. Moreover, there was no difference in the magnitude of plasma flavivirus-specific IgG levels between mothers and infants regardless of ZIKV infection status. Our data suggests that maternal ZIKV infection during pregnancy does not impair the efficiency of placental transfer of flavivirus-specific, functional, and vaccine-elicited IgG. These findings have implications for the neonatal outomes of maternal ZIKV infection and optimal administration of antibody-based ZIKV vaccines and therapeutics.

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Published In

PLoS Negl Trop Dis

DOI

EISSN

1935-2735

Publication Date

August 2019

Volume

13

Issue

8

Start / End Page

e0007648

Location

United States

Related Subject Headings

  • Zika Virus Infection
  • Zika Virus
  • Young Adult
  • Tropical Medicine
  • Prospective Studies
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Immunoglobulin G
  • Humans
  • Fetal Blood
 

Citation

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Singh, T., Lopez, C. A., Giuberti, C., Dennis, M. L., Itell, H. L., Heimsath, H. J., … Permar, S. R. (2019). Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy. PLoS Negl Trop Dis, 13(8), e0007648. https://doi.org/10.1371/journal.pntd.0007648
Singh, Tulika, Cesar A. Lopez, Camila Giuberti, Maria L. Dennis, Hannah L. Itell, Holly J. Heimsath, Helen S. Webster, et al. “Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy.PLoS Negl Trop Dis 13, no. 8 (August 2019): e0007648. https://doi.org/10.1371/journal.pntd.0007648.
Singh T, Lopez CA, Giuberti C, Dennis ML, Itell HL, Heimsath HJ, et al. Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy. PLoS Negl Trop Dis. 2019 Aug;13(8):e0007648.
Singh, Tulika, et al. “Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy.PLoS Negl Trop Dis, vol. 13, no. 8, Aug. 2019, p. e0007648. Pubmed, doi:10.1371/journal.pntd.0007648.
Singh T, Lopez CA, Giuberti C, Dennis ML, Itell HL, Heimsath HJ, Webster HS, Roark HK, Merçon de Vargas PR, Hall A, Corey RG, Swamy GK, Dietze R, Lazear HM, Permar SR. Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy. PLoS Negl Trop Dis. 2019 Aug;13(8):e0007648.

Published In

PLoS Negl Trop Dis

DOI

EISSN

1935-2735

Publication Date

August 2019

Volume

13

Issue

8

Start / End Page

e0007648

Location

United States

Related Subject Headings

  • Zika Virus Infection
  • Zika Virus
  • Young Adult
  • Tropical Medicine
  • Prospective Studies
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Immunoglobulin G
  • Humans
  • Fetal Blood