Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field.
Journal Article
Signal Amplification By Reversible Exchange, or SABRE, uses the singlet-order of parahydrogen to generate hyperpolarized signals on target nuclei, bypassing the limitations of traditional magnetic resonance. Experiments performed directly in the magnet provide a route to generate large magnetizations continuously without having to field-cycle the sample. For heteronuclear SABRE, these high-field methods have been restricted to the few SABRE complexes that exhibit efficient exchange with symmetric ligand environments as co-ligands induce chemical shift differences between the parahydrogen-derived hydrides, destroying the hyperpolarized spin order. Through careful consideration of the underlying spin physics, we introduce 1 H decoupled LIGHT-SABRE pulse sequence variants which bypasses this limitation, drastically expanding the scope of heteronuclear SABRE at high field.
Full Text
Duke Authors
Cited Authors
- Lindale, JR; Tanner, CPN; Eriksson, SL; Warren, WS
Published Date
- October 2019
Published In
Volume / Issue
- 307 /
Start / End Page
- 106577 -
PubMed ID
- 31454701
Pubmed Central ID
- 31454701
Electronic International Standard Serial Number (EISSN)
- 1096-0856
International Standard Serial Number (ISSN)
- 1090-7807
Digital Object Identifier (DOI)
- 10.1016/j.jmr.2019.106577
Language
- eng