Responses of serum chemokines to dramatic changes of air pollution levels, a panel study.

Journal Article (Journal Article)

Background: Despite the in vitro and in vivo evidence, studies are limited in evaluating whether chemokines are potential inflammatory mediators in response to air pollution exposure in humans. Methods: We conducted a panel study coinciding with the Beijing Olympics, when temporary air pollution controls were implemented. We measured a suite of serum chemokines among healthy adults before, during and after the Olympics, respectively. Linear mixed-effect models were used to evaluate changes in chemokine levels over the three time periods. Results: In response to the 50% drop in air pollution levels during the games, levels of RANTES, MCP-2, and TARC decreased by 25.8%, 20.9% and 35.3%, respectively (p  < 0.001) from pre-Olympics, and then increased by 45.8%, 34.9% and 61.5%, respectively (p  < 0.001) after the games when air pollution levels went up again. Similar patterns were observed in subgroup analyses by sex, age, smoking and body mass index. GRO-α and IL-8 decreased significantly during the games (22.5% and 30.4%), and increased non-significantly after the games. Eotaxin-1 only increased significantly from during- to post-games. Conclusions: The strongest associations with air pollution levels were observed among RANTES, TARC and MCP-2. Those chemokines may play important roles in the air pollution-induced inflammatory pathway.

Full Text

Duke Authors

Cited Authors

  • Li, Y; Bonner, MR; Browne, RW; Deng, F; Tian, L; Jim Zhang, J; Swanson, M; Rittenhouse-Olson, K; Farhat, Z; Mu, L

Published Date

  • November 2019

Published In

Volume / Issue

  • 24 / 7

Start / End Page

  • 712 - 719

PubMed ID

  • 31456427

Pubmed Central ID

  • PMC7006057

Electronic International Standard Serial Number (EISSN)

  • 1366-5804

International Standard Serial Number (ISSN)

  • 1354-750X

Digital Object Identifier (DOI)

  • 10.1080/1354750x.2019.1658803


  • eng