Association of baseline inflammatory biomarkers with cancer mortality in the REGARDS cohort.

Published online

Journal Article

This study examines the association between inflammatory biomarkers and risk of cancer mortality by race. Data were obtained from 1,856 participants in the prospective REGARDS cohort who were cancer-free at baseline, and analyzed in relation to cancer mortality prospectively. Biomarkers were log-transformed and categorized into tertiles due to non-normal distributions, and Cox proportional hazard regression models were utilized to compute hazard ratios with 95% confidence intervals using robust sandwich methods. Individuals in the highest tertile of IL-6 had over a 12-fold increased risk of cancer mortality (HR: 12.97, 95% CI: 3.46-48.63); those in the highest tertile of IL-8 had over a 2-fold increased risk of cancer mortality (HR: 2.21, 95% CI: 0.86-5.71), while those in the highest tertile of IL-10 had over a 3-fold increased risk of cancer mortality (HR: 3.06, 95% CI: 1.35-6.89). In race-stratified analysis, each unit increase in IL-6 was associated with increased risk of cancer mortality among African-Americans (HR: 3.88, 95% CI: 1.17-12.88) and Whites (5.25, 95% CI: 1.24-22.31). If replicated in larger, racially diverse prospective cohorts, these results suggest that cancer patients may benefit from clinical or lifestyle approaches to regulate systemic inflammation as a cancer prevention strategy.

Full Text

Duke Authors

Cited Authors

  • Akinyemiju, T; Moore, JX; Pisu, M; Goodman, M; Howard, VJ; Safford, M; Gilchrist, SC; Cushman, M; Long, L; Judd, SE

Published Date

  • August 6, 2019

Published In

Volume / Issue

  • 10 / 47

Start / End Page

  • 4857 - 4867

PubMed ID

  • 31448052

Pubmed Central ID

  • 31448052

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.27108

Language

  • eng

Conference Location

  • United States