Pathogenesis of Posttraumatic Osteoarthritis of the Ankle.

Journal Article (Journal Article;Review)

Ankle osteoarthritis affects a significant portion of the global adult population. Unlike other joints, arthritis of the ankle often develops as a response to traumatic injury (intra-articular fracture) of the ankle joints. The full mechanism leading to posttraumatic osteoarthritis of the ankle (PTOAA) is poorly understood. These deficits in knowledge pose challenges in the management of the disease. Adequate surgical reduction of fractured ankle joints remains the gold standard in prevention. The purpose of this review is to thoroughly delineate the known pathogenesis of PTOAA, and provide critical updates on this pathology and new avenues to provide therapeutic management of the disease.

Full Text

Duke Authors

Cited Authors

  • Nwankwo, EC; Labaran, LA; Athas, V; Olson, S; Adams, SB

Published Date

  • October 2019

Published In

Volume / Issue

  • 50 / 4

Start / End Page

  • 529 - 537

PubMed ID

  • 31466668

Electronic International Standard Serial Number (EISSN)

  • 1558-1373

Digital Object Identifier (DOI)

  • 10.1016/j.ocl.2019.05.008


  • eng

Conference Location

  • United States