Skip to main content

Optical coherence refraction tomography.

Publication ,  Journal Article
Zhou, KC; Qian, R; Degan, S; Farsiu, S; Izatt, JA
Published in: Nature photonics
November 2019

Optical coherence tomography (OCT) is a cross-sectional, micron-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice lateral resolution to achieve long depths of focus for bulk tissue imaging, and hence tend to have better axial than lateral resolution. Such anisotropic resolution can obscure fine ultrastructural features. Furthermore, conventional OCT suffers from refraction-induced image distortions. Here, we introduce optical coherence refraction tomography (OCRT), which extends the superior axial resolution to the lateral dimension, synthesising undistorted cross-sectional image reconstructions from multiple conventional images acquired with angular diversity. In correcting refraction-induced distortions to register the OCT images, OCRT also achieves spatially resolved refractive index imaging. We demonstrate >3-fold improvement in lateral resolution as well as speckle reduction in imaging tissue ultrastructure, consistent with histology. With further optimisation in optical designs to incorporate angular diversity into clinical instruments, OCRT could be widely applied as an enhancement over conventional OCT.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nature photonics

DOI

EISSN

1749-4893

ISSN

1749-4885

Publication Date

November 2019

Volume

13

Issue

11

Start / End Page

794 / 802

Related Subject Headings

  • Optoelectronics & Photonics
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 02 Physical Sciences
  • 01 Mathematical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhou, K. C., Qian, R., Degan, S., Farsiu, S., & Izatt, J. A. (2019). Optical coherence refraction tomography. Nature Photonics, 13(11), 794–802. https://doi.org/10.1038/s41566-019-0508-1
Zhou, Kevin C., Ruobing Qian, Simone Degan, Sina Farsiu, and Joseph A. Izatt. “Optical coherence refraction tomography.Nature Photonics 13, no. 11 (November 2019): 794–802. https://doi.org/10.1038/s41566-019-0508-1.
Zhou KC, Qian R, Degan S, Farsiu S, Izatt JA. Optical coherence refraction tomography. Nature photonics. 2019 Nov;13(11):794–802.
Zhou, Kevin C., et al. “Optical coherence refraction tomography.Nature Photonics, vol. 13, no. 11, Nov. 2019, pp. 794–802. Epmc, doi:10.1038/s41566-019-0508-1.
Zhou KC, Qian R, Degan S, Farsiu S, Izatt JA. Optical coherence refraction tomography. Nature photonics. 2019 Nov;13(11):794–802.

Published In

Nature photonics

DOI

EISSN

1749-4893

ISSN

1749-4885

Publication Date

November 2019

Volume

13

Issue

11

Start / End Page

794 / 802

Related Subject Headings

  • Optoelectronics & Photonics
  • 51 Physical sciences
  • 49 Mathematical sciences
  • 02 Physical Sciences
  • 01 Mathematical Sciences