Axis specification in animal development.


Journal Article (Review)

Axis specification is the first step in defining specific regions of the developing embryo. Embryos exploit asymmetries, either pre-existing in the egg or triggered by external cues, to establish embryonic axes. The axial information is then used to generate regional differences within the embryo. In this review, we discuss experiments in animals which address three questions: whether the unfertilized egg is constructed with pre-determined axes, what cues are used to specify the embryonic axes, and how these cues are interpreted to generate the initial regional differences within the embryo. Based on mapping the data onto an animal phylogeny, we then propose a scenario for how this primary developmental decision occurred in ancestral metazoans.

Full Text

Cited Authors

  • Goldstein, B; Freeman, G

Published Date

  • February 1997

Published In

Volume / Issue

  • 19 / 2

Start / End Page

  • 105 - 116

PubMed ID

  • 9046240

Pubmed Central ID

  • 9046240

Electronic International Standard Serial Number (EISSN)

  • 1521-1878

International Standard Serial Number (ISSN)

  • 0265-9247

Digital Object Identifier (DOI)

  • 10.1002/bies.950190205


  • eng