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The PAR proteins: fundamental players in animal cell polarization.

Publication ,  Journal Article
Goldstein, B; Macara, IG
Published in: Developmental cell
November 2007

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning in the early embryo of C. elegans, and encode six different proteins required for asymmetric cell division by the worm zygote. Some of the PAR proteins are localized asymmetrically and form physical complexes with one another. Strikingly, the PAR proteins have been found to regulate cell polarization in many different contexts in diverse animals, suggesting they form part of an ancient and fundamental mechanism for cell polarization. Although the picture of how the PAR proteins function remains incomplete, cell biology and biochemistry are beginning to explain how PAR proteins polarize cells.

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Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

November 2007

Volume

13

Issue

5

Start / End Page

609 / 622

Related Subject Headings

  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Neurons
  • Mutation
  • Epithelial Cells
  • Drosophila
  • Developmental Biology
  • Cell Polarity
  • Cell Movement
  • Cell Differentiation
 

Citation

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Goldstein, B., & Macara, I. G. (2007). The PAR proteins: fundamental players in animal cell polarization. Developmental Cell, 13(5), 609–622. https://doi.org/10.1016/j.devcel.2007.10.007
Goldstein, Bob, and Ian G. Macara. “The PAR proteins: fundamental players in animal cell polarization.Developmental Cell 13, no. 5 (November 2007): 609–22. https://doi.org/10.1016/j.devcel.2007.10.007.
Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Developmental cell. 2007 Nov;13(5):609–22.
Goldstein, Bob, and Ian G. Macara. “The PAR proteins: fundamental players in animal cell polarization.Developmental Cell, vol. 13, no. 5, Nov. 2007, pp. 609–22. Epmc, doi:10.1016/j.devcel.2007.10.007.
Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Developmental cell. 2007 Nov;13(5):609–622.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

November 2007

Volume

13

Issue

5

Start / End Page

609 / 622

Related Subject Headings

  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Neurons
  • Mutation
  • Epithelial Cells
  • Drosophila
  • Developmental Biology
  • Cell Polarity
  • Cell Movement
  • Cell Differentiation