Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons.

Published

Journal Article

The detection of odorants with high sensitivity and specificity utilizes specialized transduction proteins that may be assembled into complexes to afford enhanced speed and efficiency in olfactory neurons. We have used a differential cDNA screening technique to identify novel gene products that display restricted expression within the olfactory epithelium. Here we report the characterization of an olfactory neuronal protein, SLP3, which shares extensive homology with the stomatin family of membrane proteins. Other stomatin family members have been implicated in specific interactions with ion channels and G protein-coupled receptors. The pattern of SLP3 mRNA expression during embryonic development and the subcellular localization of the SLP3 protein in mature olfactory neurons observed here is consistent with a specific role for this protein in the assembly, translocation, or function of the odorant transduction complex in olfactory neurons.

Full Text

Duke Authors

Cited Authors

  • Goldstein, BJ; Kulaga, HM; Reed, RR

Published Date

  • March 2003

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 74 - 82

PubMed ID

  • 12239636

Pubmed Central ID

  • 12239636

International Standard Serial Number (ISSN)

  • 1525-3961

Digital Object Identifier (DOI)

  • 10.1007/s10162-002-2039-5

Language

  • eng

Conference Location

  • United States