An atypical case of fatal zygomycosis: simultaneous cutaneous and laryngeal infection in a patient with a non-neutropenic solid prostatic tumor.
We describe what we believe is the first reported case of simultaneous highly invasive cutaneous and laryngopharyngeal zygomycosis in a non-neutropenic, nondiabetic but immunosuppressed patient with prostate cancer. An invasive fungal process was not suspected until late in the patient's hospital course; when it was, a tracheotomy and direct laryngoscopic biopsies were performed. Unresectable invasive zygomycosis with Rhizopus rhizopodiformis was diagnosed. The patient was managed with liposomal amphotericin B initially and later with palliative medical therapy until he died. This case emphasizes the need for a rapid and specific diagnosis with timely introduction of appropriate antifungal management, particularly now that voriconazole is frequently used as empiric prophylaxis against aspergillosis in high-risk patients.
Duke Scholars
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Related Subject Headings
- Rhizopus
- Prostatic Neoplasms
- Pharyngeal Diseases
- Otorhinolaryngology
- Mucormycosis
- Male
- Laryngeal Diseases
- Immunocompromised Host
- Humans
- Fatal Outcome
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Rhizopus
- Prostatic Neoplasms
- Pharyngeal Diseases
- Otorhinolaryngology
- Mucormycosis
- Male
- Laryngeal Diseases
- Immunocompromised Host
- Humans
- Fatal Outcome