An atypical case of fatal zygomycosis: simultaneous cutaneous and laryngeal infection in a patient with a non-neutropenic solid prostatic tumor.

Journal Article (Journal Article;Review)

We describe what we believe is the first reported case of simultaneous highly invasive cutaneous and laryngopharyngeal zygomycosis in a non-neutropenic, nondiabetic but immunosuppressed patient with prostate cancer. An invasive fungal process was not suspected until late in the patient's hospital course; when it was, a tracheotomy and direct laryngoscopic biopsies were performed. Unresectable invasive zygomycosis with Rhizopus rhizopodiformis was diagnosed. The patient was managed with liposomal amphotericin B initially and later with palliative medical therapy until he died. This case emphasizes the need for a rapid and specific diagnosis with timely introduction of appropriate antifungal management, particularly now that voriconazole is frequently used as empiric prophylaxis against aspergillosis in high-risk patients.

Full Text

Duke Authors

Cited Authors

  • Johnson, KE; Leahy, K; Owens, C; Blankson, JN; Merz, WG; Goldstein, BJ

Published Date

  • March 2008

Published In

Volume / Issue

  • 87 / 3

Start / End Page

  • 152 - 155

PubMed ID

  • 18404912

International Standard Serial Number (ISSN)

  • 0145-5613


  • eng

Conference Location

  • United States