Transplantation of multipotent progenitors from the adult olfactory epithelium.
Journal Article (Journal Article)
Mammalian olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroepithelial reconstitution. In contrast to their normal neuronal fate in situ, grafted precursors harvested from bulbectomized donors produced non-neuronal cells as well as neurons. These results demonstrate that epithelial precursors activated following olfactory bulbectomy are not irreversibly committed to making neurons. Thus, olfactory progenitors are subject to a form of feedback control in vivo that regulates the types of cells that they produce within a broader-than-neuronal repertoire.
Full Text
Duke Authors
Cited Authors
- Goldstein, BJ; Fang, H; Youngentob, SL; Schwob, JE
Published Date
- May 11, 1998
Published In
Volume / Issue
- 9 / 7
Start / End Page
- 1611 - 1617
PubMed ID
- 9631475
International Standard Serial Number (ISSN)
- 0959-4965
Digital Object Identifier (DOI)
- 10.1097/00001756-199805110-00065
Language
- eng
Conference Location
- England