Transplantation of multipotent progenitors from the adult olfactory epithelium.

Journal Article (Journal Article)

Mammalian olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroepithelial reconstitution. In contrast to their normal neuronal fate in situ, grafted precursors harvested from bulbectomized donors produced non-neuronal cells as well as neurons. These results demonstrate that epithelial precursors activated following olfactory bulbectomy are not irreversibly committed to making neurons. Thus, olfactory progenitors are subject to a form of feedback control in vivo that regulates the types of cells that they produce within a broader-than-neuronal repertoire.

Full Text

Duke Authors

Cited Authors

  • Goldstein, BJ; Fang, H; Youngentob, SL; Schwob, JE

Published Date

  • May 11, 1998

Published In

Volume / Issue

  • 9 / 7

Start / End Page

  • 1611 - 1617

PubMed ID

  • 9631475

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199805110-00065


  • eng

Conference Location

  • England