Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.

Journal Article (Journal Article;Review)

Diabetic retinopathy (DR) and retinal vein occlusion (RVO) are the two most common retinal vascular diseases and are major causes of vision loss and blindness worldwide. Recent and ongoing development of medical therapies including anti-vascular endothelial growth factor and corticosteroid drugs for treatment of these diseases have greatly improved the care of afflicted patients. However, severe manifestations of retinal vascular disease result in persistent macular edema, progressive retinal ischemia and incomplete visual recovery. Additionally, choroidal vascular diseases including neovascular age-related macular degeneration (NVAMD) and central serous chorioretinopathy (CSCR) cause vision loss for which current treatments are incompletely effective in some cases and highly burdensome in others. In recent years, aldosterone has gained attention as a contributor to the various deleterious effects of retinal and choroidal vascular diseases via a variety of mechanisms in several retinal cell types. The following is a review of the role of aldosterone in retinal and choroidal vascular diseases as well as our current understanding of the mechanisms by which aldosterone mediates these effects.

Full Text

Duke Authors

Cited Authors

  • Allingham, MJ; Mettu, PS; Cousins, SW

Published Date

  • November 2019

Published In

Volume / Issue

  • 188 /

Start / End Page

  • 107788 -

PubMed ID

  • 31479654

Pubmed Central ID

  • PMC6802292

Electronic International Standard Serial Number (EISSN)

  • 1096-0007

Digital Object Identifier (DOI)

  • 10.1016/j.exer.2019.107788


  • eng

Conference Location

  • England