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Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.

Publication ,  Journal Article
Allingham, MJ; Mettu, PS; Cousins, SW
Published in: Exp Eye Res
November 2019

Diabetic retinopathy (DR) and retinal vein occlusion (RVO) are the two most common retinal vascular diseases and are major causes of vision loss and blindness worldwide. Recent and ongoing development of medical therapies including anti-vascular endothelial growth factor and corticosteroid drugs for treatment of these diseases have greatly improved the care of afflicted patients. However, severe manifestations of retinal vascular disease result in persistent macular edema, progressive retinal ischemia and incomplete visual recovery. Additionally, choroidal vascular diseases including neovascular age-related macular degeneration (NVAMD) and central serous chorioretinopathy (CSCR) cause vision loss for which current treatments are incompletely effective in some cases and highly burdensome in others. In recent years, aldosterone has gained attention as a contributor to the various deleterious effects of retinal and choroidal vascular diseases via a variety of mechanisms in several retinal cell types. The following is a review of the role of aldosterone in retinal and choroidal vascular diseases as well as our current understanding of the mechanisms by which aldosterone mediates these effects.

Duke Scholars

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

November 2019

Volume

188

Start / End Page

107788

Location

England

Related Subject Headings

  • Retinal Vessels
  • Retinal Diseases
  • Retina
  • Renin-Angiotensin System
  • Ophthalmology & Optometry
  • Humans
  • Ciliary Arteries
  • Choroid Diseases
  • Aldosterone
  • 3212 Ophthalmology and optometry
 

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Allingham, M. J., Mettu, P. S., & Cousins, S. W. (2019). Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms. Exp Eye Res, 188, 107788. https://doi.org/10.1016/j.exer.2019.107788
Allingham, Michael J., Priyatham S. Mettu, and Scott W. Cousins. “Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.Exp Eye Res 188 (November 2019): 107788. https://doi.org/10.1016/j.exer.2019.107788.
Allingham MJ, Mettu PS, Cousins SW. Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms. Exp Eye Res. 2019 Nov;188:107788.
Allingham, Michael J., et al. “Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.Exp Eye Res, vol. 188, Nov. 2019, p. 107788. Pubmed, doi:10.1016/j.exer.2019.107788.
Allingham MJ, Mettu PS, Cousins SW. Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms. Exp Eye Res. 2019 Nov;188:107788.
Journal cover image

Published In

Exp Eye Res

DOI

EISSN

1096-0007

Publication Date

November 2019

Volume

188

Start / End Page

107788

Location

England

Related Subject Headings

  • Retinal Vessels
  • Retinal Diseases
  • Retina
  • Renin-Angiotensin System
  • Ophthalmology & Optometry
  • Humans
  • Ciliary Arteries
  • Choroid Diseases
  • Aldosterone
  • 3212 Ophthalmology and optometry