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Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension.

Publication ,  Journal Article
Shelburne, NJ; Parikh, KS; Chiswell, K; Shaw, LK; Sivak, J; Arges, K; Tomfohr, J; Velazquez, EJ; Kisslo, J; Samad, Z; Rajagopal, S
Published in: Am J Cardiol
October 15, 2019

Echocardiography is a key tool in the management of patients with pulmonary arterial hypertension (PAH), but many potential parameters could be used to assess response to therapy. In this retrospective study of 48 patients with severe PAH at baseline, we examined echocardiographic variables before and after initiation of PAH-specific therapy to evaluate which measures of right ventricular (RV) function best correlated with clinical response to therapy as assessed by 6-minute walk distance (6MWD) and 3-year all-cause mortality. Tricuspid annular plane systolic excursion (TAPSE), mid-RV and basal-RV diameters, RV systolic pressure, and RV global longitudinal strain were all found to significantly improve after initiation of a PAH therapy. Decreases in right atrial area (r = -0.50, p = 0.002) and mid-RV diameter (r = -0.36, p = 0.03) were most strongly correlated with improvement in 6MWD. Pretreatment values of RA area (hazard ratio [HR] per 1 SD: 2.72; 95% confidence interval [CI] 1.58, 4.69), mid-RV diameter (HR 2.03; 1.20, 3.45), basal-RV diameter (HR 2.27; 1.40, 3.70), and RV global longitudinal strain (HR 2.36; 1.22, 4.56) were all associated with mortality risk. 6MWD and TAPSE were the 2 variables for which pretreatment measures (6MWD - HR 0.35; 0.17, 0.72; TAPSE - HR 0.41; 0.21, 0.82) and change with treatment (6MWD - HR 0.26; 0.10, 0.64; TAPSE - HR 0.40; 0.21, 0.77) were both significantly associated with 3-year mortality. Change in RV systolic pressure with treatment was significantly associated with mortality (HR 2.55; 1.23, 5.28,) but pretreatment baseline had no association (HR 1.48; 0.72, 3.06). Although many echocardiographic parameters change with initiation of PAH treatment, the strong association of both baseline TAPSE and change in TAPSE with mortality supports the ongoing use of TAPSE as an important measure in the assessment of disease severity and treatment response in PAH.

Duke Scholars

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 15, 2019

Volume

124

Issue

8

Start / End Page

1298 / 1304

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Function, Right
  • Survival Rate
  • Stroke Volume
  • Severity of Illness Index
  • Retrospective Studies
  • Pulmonary Arterial Hypertension
  • Prognosis
  • North Carolina
  • Middle Aged
 

Citation

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Shelburne, N. J., Parikh, K. S., Chiswell, K., Shaw, L. K., Sivak, J., Arges, K., … Rajagopal, S. (2019). Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension. Am J Cardiol, 124(8), 1298–1304. https://doi.org/10.1016/j.amjcard.2019.07.026
Shelburne, Nicholas J., Kishan S. Parikh, Karen Chiswell, Linda K. Shaw, Joseph Sivak, Kristine Arges, Jennifer Tomfohr, et al. “Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension.Am J Cardiol 124, no. 8 (October 15, 2019): 1298–1304. https://doi.org/10.1016/j.amjcard.2019.07.026.
Shelburne NJ, Parikh KS, Chiswell K, Shaw LK, Sivak J, Arges K, et al. Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension. Am J Cardiol. 2019 Oct 15;124(8):1298–304.
Shelburne, Nicholas J., et al. “Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension.Am J Cardiol, vol. 124, no. 8, Oct. 2019, pp. 1298–304. Pubmed, doi:10.1016/j.amjcard.2019.07.026.
Shelburne NJ, Parikh KS, Chiswell K, Shaw LK, Sivak J, Arges K, Tomfohr J, Velazquez EJ, Kisslo J, Samad Z, Rajagopal S. Echocardiographic Assessment of Right Ventricular Function and Response to Therapy in Pulmonary Arterial Hypertension. Am J Cardiol. 2019 Oct 15;124(8):1298–1304.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 15, 2019

Volume

124

Issue

8

Start / End Page

1298 / 1304

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Function, Right
  • Survival Rate
  • Stroke Volume
  • Severity of Illness Index
  • Retrospective Studies
  • Pulmonary Arterial Hypertension
  • Prognosis
  • North Carolina
  • Middle Aged