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One small step for mice, one giant leap for GWAS?

Publication ,  Journal Article
Herman, MA; Campbell, JE; D'Alessio, DA
Published in: J Clin Invest
October 1, 2019

Genome-wide association studies (GWAS) have provided a wealth of information on potential disease-associated genes in the human population. In particular, several loci have been associated with type 2 diabetes (T2D). However, due to the complexity of the disease, it has been a challenge to unravel the exact effects of specific loci on T2D pathogenesis. In this issue of the JCI, Keller and colleagues developed a systems genetic approach to identify insulin secretion-associated genes in nondiabetic mice followed by tissue-level and functional phenotyping. Several of the loci identified were syntenic with human T2D-related loci, indicating that this approach may be feasible for discerning genetic variation in nondiabetic individuals that may lead to the development of T2D.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

October 1, 2019

Volume

129

Issue

10

Start / End Page

4083 / 4085

Location

United States

Related Subject Headings

  • Mice, Inbred Strains
  • Mice
  • Insulin Secretion
  • Immunology
  • Humans
  • Genome-Wide Association Study
  • Diabetes Mellitus, Type 2
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
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ICMJE
MLA
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Herman, M. A., Campbell, J. E., & D’Alessio, D. A. (2019). One small step for mice, one giant leap for GWAS? J Clin Invest, 129(10), 4083–4085. https://doi.org/10.1172/JCI131650
Herman, Mark A., Jonathan E. Campbell, and David A. D’Alessio. “One small step for mice, one giant leap for GWAS?J Clin Invest 129, no. 10 (October 1, 2019): 4083–85. https://doi.org/10.1172/JCI131650.
Herman MA, Campbell JE, D’Alessio DA. One small step for mice, one giant leap for GWAS? J Clin Invest. 2019 Oct 1;129(10):4083–5.
Herman, Mark A., et al. “One small step for mice, one giant leap for GWAS?J Clin Invest, vol. 129, no. 10, Oct. 2019, pp. 4083–85. Pubmed, doi:10.1172/JCI131650.
Herman MA, Campbell JE, D’Alessio DA. One small step for mice, one giant leap for GWAS? J Clin Invest. 2019 Oct 1;129(10):4083–4085.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

October 1, 2019

Volume

129

Issue

10

Start / End Page

4083 / 4085

Location

United States

Related Subject Headings

  • Mice, Inbred Strains
  • Mice
  • Insulin Secretion
  • Immunology
  • Humans
  • Genome-Wide Association Study
  • Diabetes Mellitus, Type 2
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences