High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China.

Journal Article (Journal Article)

Background

China is thought to be a hotspot for zoonotic influenza virus emergence, yet there have been few prospective studies examining the occupational risks of such infections.

Methods

We present the first 2 years of data collected from a 5-year, prospective, cohort study of swine-exposed and -unexposed participants at 6 swine farms in China. We conducted serological and virological surveillance to examine evidence for swine influenza A virus infection in humans.

Results

Of the 658 participants (521 swine-exposed and 137 swine-unexposed), 207 (31.5%) seroconverted against at least 1 swine influenza virus subtype (swine H1N1 or H3N2). Swine-exposed participants' microneutralization titers, especially those enrolled at confined animal feeding operations (CAFOs), were higher against the swine H1N1 virus than were other participants at 12 and 24 months. Despite elevated titers, among the 187 study subjects for whom we had complete follow-up, participants working at swine CAFOs had significantly greater odds of seroconverting against both the swine H1N1 (odds ratio [OR] 19.16, 95% confidence interval [CI] 3.55-358.65) and swine H3N2 (OR 2.97, 95% CI 1.16-8.01) viruses, compared to unexposed and non-CAFO swine workers with less intense swine exposure.

Conclusions

While some of the observed increased risk against swine viruses may have been explained by exposure to human influenza strains, study data suggest that even with elevated preexisting antibodies, swine-exposed workers were at high risk of infection with enzootic swine influenza A viruses.

Full Text

Duke Authors

Cited Authors

  • Borkenhagen, LK; Wang, G-L; Simmons, RA; Bi, Z-Q; Lu, B; Wang, X-J; Wang, C-X; Chen, S-H; Song, S-X; Li, M; Zhao, T; Wu, M-N; Park, LP; Cao, W-C; Ma, M-J; Gray, GC

Published Date

  • July 2020

Published In

Volume / Issue

  • 71 / 3

Start / End Page

  • 622 - 629

PubMed ID

  • 31504322

Pubmed Central ID

  • PMC7108185

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

International Standard Serial Number (ISSN)

  • 1058-4838

Digital Object Identifier (DOI)

  • 10.1093/cid/ciz865

Language

  • eng