Poly(propylene fumarate) stars, using architecture to reduce the viscosity of 3D printable resins

Journal Article (Journal Article)

Additive manufacturing is changing tissue engineering by offering pathways to otherwise unattainable, highly complex scaffold morphologies. Linear poly(propylene fumarate) (PPF) oligomers have demonstrated remarkable properties for 3D printing of porous gyroid scaffolds using continuous digital light processing (cDLP). Nevertheless, the narrow molar mass range with suitable viscosity properties for printing severely limits the printing speed, the breadth of mechanical properties, and the resorption window of the scaffolds. To overcome this constraint, we report the divergent synthesis of four-arm PPF using the sugar-based alcohol meso-erythritol as an initiator. Using a combination of 1H NMR spectroscopy, size exclusion chromatography (SEC), MALDI-ToF spectrometry and viscosity measurements, the well-defined star-shape architecture was confirmed. Subsequently, printable resins based on star PPF were prepared and showed complex viscosity decreasing as the total increases, allowing rapid printing of PPF with nearly eight times larger than the largest linear PPF oligomer printed previously.

Full Text

Duke Authors

Cited Authors

  • Le Fer, G; Luo, Y; Becker, ML

Published Date

  • September 14, 2019

Published In

Volume / Issue

  • 10 / 34

Start / End Page

  • 4655 - 4664

Electronic International Standard Serial Number (EISSN)

  • 1759-9962

International Standard Serial Number (ISSN)

  • 1759-9954

Digital Object Identifier (DOI)

  • 10.1039/c9py00738e

Citation Source

  • Scopus