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B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.

Publication ,  Journal Article
Griss, J; Bauer, W; Wagner, C; Simon, M; Chen, M; Grabmeier-Pfistershammer, K; Maurer-Granofszky, M; Roka, F; Penz, T; Bock, C; Zhang, G ...
Published in: Nat Commun
September 13, 2019

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor associated B cells are vital to melanoma associated inflammation. Human B cells express pro- and anti-inflammatory factors and differentiate into plasmablast-like cells when exposed to autologous melanoma secretomes in vitro. This plasmablast-like phenotype can be reconciled in human melanomas where plasmablast-like cells also express T cell-recruiting chemokines CCL3, CCL4, CCL5. Depletion of B cells in melanoma patients by anti-CD20 immunotherapy decreases tumor associated inflammation and CD8+ T cell numbers. Plasmablast-like cells also increase PD-1+ T cell activation through anti-PD-1 blockade in vitro and their frequency in pretherapy melanomas predicts response and survival to immune checkpoint blockade. Tumor associated B cells therefore orchestrate and sustain melanoma inflammation and may represent a predictor for survival and response to immune checkpoint blockade therapy.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

September 13, 2019

Volume

10

Issue

1

Start / End Page

4186

Location

England

Related Subject Headings

  • Programmed Cell Death 1 Receptor
  • Melanoma
  • Inflammation
  • In Vitro Techniques
  • Immunotherapy
  • Humans
  • Chemokine CCL5
  • Chemokine CCL4
  • Chemokine CCL3
  • Cell Line, Tumor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Griss, J., Bauer, W., Wagner, C., Simon, M., Chen, M., Grabmeier-Pfistershammer, K., … Wagner, S. N. (2019). B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun, 10(1), 4186. https://doi.org/10.1038/s41467-019-12160-2
Griss, Johannes, Wolfgang Bauer, Christine Wagner, Martin Simon, Minyi Chen, Katharina Grabmeier-Pfistershammer, Margarita Maurer-Granofszky, et al. “B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.Nat Commun 10, no. 1 (September 13, 2019): 4186. https://doi.org/10.1038/s41467-019-12160-2.
Griss J, Bauer W, Wagner C, Simon M, Chen M, Grabmeier-Pfistershammer K, et al. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun. 2019 Sep 13;10(1):4186.
Griss, Johannes, et al. “B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.Nat Commun, vol. 10, no. 1, Sept. 2019, p. 4186. Pubmed, doi:10.1038/s41467-019-12160-2.
Griss J, Bauer W, Wagner C, Simon M, Chen M, Grabmeier-Pfistershammer K, Maurer-Granofszky M, Roka F, Penz T, Bock C, Zhang G, Herlyn M, Glatz K, Läubli H, Mertz KD, Petzelbauer P, Wiesner T, Hartl M, Pickl WF, Somasundaram R, Steinberger P, Wagner SN. B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma. Nat Commun. 2019 Sep 13;10(1):4186.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

September 13, 2019

Volume

10

Issue

1

Start / End Page

4186

Location

England

Related Subject Headings

  • Programmed Cell Death 1 Receptor
  • Melanoma
  • Inflammation
  • In Vitro Techniques
  • Immunotherapy
  • Humans
  • Chemokine CCL5
  • Chemokine CCL4
  • Chemokine CCL3
  • Cell Line, Tumor