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Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis.

Publication ,  Journal Article
Klement, RJ; Champ, CE; Otto, C; Kämmerer, U
Published in: PLoS One
2016

BACKGROUND: Currently ketogenic diets (KDs) are hyped as an anti-tumor intervention aimed at exploiting the metabolic abnormalities of cancer cells. However, while data in humans is sparse, translation of murine tumor models to the clinic is further hampered by small sample sizes, heterogeneous settings and mixed results concerning tumor growth retardation. The aim was therefore to synthesize the evidence for a growth inhibiting effect of KDs when used as a monotherapy in mice. METHODS: We conducted a Bayesian random effects meta-analysis on all studies assessing the survival (defined as the time to reach a pre-defined endpoint such as tumor volume) of mice on an unrestricted KD compared to a high carbohydrate standard diet (SD). For 12 studies meeting the inclusion criteria either a mean survival time ratio (MR) or hazard ratio (HR) between the KD and SD groups could be obtained. The posterior estimates for the MR and HR averaged over four priors on the between-study heterogeneity τ2 were MR = 0.85 (95% highest posterior density interval (HPDI) = [0.73, 0.97]) and HR = 0.55 (95% HPDI = [0.26, 0.87]), indicating a significant overall benefit of the KD in terms of prolonged mean survival times and reduced hazard rate. All studies that used a brain tumor model also chose a late starting point for the KD (at least one day after tumor initiation) which accounted for 26% of the heterogeneity. In this subgroup the KD was less effective (MR = 0.89, 95% HPDI = [0.76, 1.04]). CONCLUSIONS: There was an overall tumor growth delaying effect of unrestricted KDs in mice. Future experiments should aim at differentiating the effects of KD timing versus tumor location, since external evidence is currently consistent with an influence of both of these factors.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

5

Start / End Page

e0155050

Location

United States

Related Subject Headings

  • Neoplasms
  • Mice
  • General Science & Technology
  • Diet, Ketogenic
  • Animals
 

Citation

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Klement, R. J., Champ, C. E., Otto, C., & Kämmerer, U. (2016). Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis. PLoS One, 11(5), e0155050. https://doi.org/10.1371/journal.pone.0155050
Klement, Rainer J., Colin E. Champ, Christoph Otto, and Ulrike Kämmerer. “Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis.PLoS One 11, no. 5 (2016): e0155050. https://doi.org/10.1371/journal.pone.0155050.
Klement RJ, Champ CE, Otto C, Kämmerer U. Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis. PLoS One. 2016;11(5):e0155050.
Klement, Rainer J., et al. “Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis.PLoS One, vol. 11, no. 5, 2016, p. e0155050. Pubmed, doi:10.1371/journal.pone.0155050.
Klement RJ, Champ CE, Otto C, Kämmerer U. Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis. PLoS One. 2016;11(5):e0155050.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

5

Start / End Page

e0155050

Location

United States

Related Subject Headings

  • Neoplasms
  • Mice
  • General Science & Technology
  • Diet, Ketogenic
  • Animals